Self-assembly of the monohydroxy triterpenoid lupeol yielding nano-fibers, sheets and gel: environmental and drug delivery applications.

Lupeol is a medicinally important naturally abundant triterpenoid having a 6-6-6-6-5 fused pentacyclic backbone and one polar secondary "-OH" group at the C3 position of the "A" ring. It was extracted from the dried outer bark of and its self-assembly properties were investigated in different neat organic as well as aquous-organic binary liquid mixtures. The triterpenoid having only one polar "-OH" group and a rigid lipophilic backbone self-assembled in neat organic non-polar liquids like -hexane, -heptane, -octane and polar liquids like DMSO, DMF, DMSO-HO, DMF-HO, and EtOH-HO yielding supramolecular gels formation of nano to micrometre long self-assembled fibrillar networks (SAFINs). Morphological investigation of the self-assemblies was carried out by field emission scanning electron microscopy, high resolution transmission electron microscopy, atomic force microscopy, optical microscopy, concentration dependent FTIR and wide angle X-ray diffraction studies. The mechanical properties of the gels were studied by concentration dependent rheological studies in different solvents. The gels were capable of removing toxic micro-pollutants like rhodamine-B and 5,6-carboxyfluorescein as well as the toxic heavy metal Cr(vi) from contaminated water. Moreover release of the chemotherapeutic drug doxorubicin from a drug loaded gel in PBS buffer at pH 7.2 has also been demonstrated by spectrophotometry.