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天然乌苏烷型二羟基三萜酸——科罗索酸的囊泡自组装

Vesicular self-assembly of a natural ursane-type dihydroxy-triterpenoid corosolic acid.

作者信息

Bag Braja G, Garai Chhabi, Ghorai Subrata

机构信息

Department of Chemistry and Chemical Technology, Vidyasagar University Midnapore 721102 West Bengal India

出版信息

RSC Adv. 2019 May 15;9(27):15190-15195. doi: 10.1039/c9ra02801c. eCollection 2019 May 14.

DOI:10.1039/c9ra02801c
PMID:35514858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9064250/
Abstract

Corosolic acid, a natural ursane-type 6-6-6-6-6 pentacyclic dihydroxy triterpenic acid, is a well known antidiabetic compound extractable from leaves of . In this manuscript we have reported the self-assembly properties of corosolic acid in different liquids. The compound undergoes self-assembly to give vesicular morphology in different aqueous organic liquids. Supramolecular gels were also obtained in some aqueous binary liquids such as ethanol-water and dimethyl formamide-water. The morphology of the self-assemblies of corosolic acid were characterized by using different microscopic techniques like optical microscopy, field emission scanning electron microscopy, transmission electron microscopy, atomic force microscopy as well as XRD and FTIR studies. We also demonstrated the application of vesicular self-assemblies for the entrapment and release of fluorophores including an anticancer drug.

摘要

科罗索酸是一种天然的乌苏烷型6-6-6-6-6五环二羟基三萜酸，是一种可从[植物名称]叶子中提取的著名抗糖尿病化合物。在本论文中，我们报道了科罗索酸在不同液体中的自组装性质。该化合物在不同的水-有机液体中进行自组装，形成囊泡形态。在一些二元水液体如乙醇-水和二甲基甲酰胺-水中也获得了超分子凝胶。通过光学显微镜、场发射扫描电子显微镜、透射电子显微镜、原子力显微镜以及XRD和FTIR研究等不同的微观技术对科罗索酸自组装体的形态进行了表征。我们还展示了囊泡自组装体在包括抗癌药物在内的荧光团的包封和释放方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/49f314a2bd32/c9ra02801c-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/07c903910b7b/c9ra02801c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/17ec5be090cd/c9ra02801c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/b65d145e0080/c9ra02801c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/4d99d8975976/c9ra02801c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/a96100d48772/c9ra02801c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/3253b8ae651d/c9ra02801c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/081a77712165/c9ra02801c-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/30d668aa0aee/c9ra02801c-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/49f314a2bd32/c9ra02801c-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/07c903910b7b/c9ra02801c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/17ec5be090cd/c9ra02801c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/b65d145e0080/c9ra02801c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/4d99d8975976/c9ra02801c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/a96100d48772/c9ra02801c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/3253b8ae651d/c9ra02801c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/081a77712165/c9ra02801c-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/30d668aa0aee/c9ra02801c-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0841/9064250/49f314a2bd32/c9ra02801c-f9.jpg

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