Garty G, Harken A D, Brenner D J
Radiological Research Accelerator Facility, Columbia University, 136 S. Broadway, Irvington, NY 10533, U.S.A.
J Instrum. 2022 Feb;17(2). doi: 10.1088/1748-0221/17/02/t02002. Epub 2022 Feb 8.
Standard dosimetry protocols exist for highly penetrating photon and particle beams used in the clinic and in research. However, these protocols cannot be directly applied to shallow penetration MeV-range ion beams. The Radiological Research Accelerator Facility has been using such beams for almost 50 years to irradiate cell monolayers, using self-developed dosimetry, based on tissue equivalent ionization chambers. To better align with the internationally accepted standards, we describe implementation of a commercial, NIST-traceable, air-filled ionization chamber for measurement of absorbed dose to water from low energy ions, using radiation quality correction factors calculated using TRS-398 recommendations. The reported dose does not depend on the ionization density in the range of 10-150 keV/μm.
临床上和研究中使用的高穿透性光子和粒子束有标准剂量测定协议。然而,这些协议不能直接应用于浅穿透的兆电子伏特范围离子束。放射研究加速器设施使用这类束流照射细胞单层已近50年,采用基于组织等效电离室的自行开发的剂量测定法。为了更好地符合国际公认标准,我们描述了一种商业的、可溯源至美国国家标准与技术研究院(NIST)的充气电离室的实施情况,该电离室用于测量低能离子在水中的吸收剂量,使用根据TRS-398建议计算的辐射质量校正因子。所报告的剂量在10 - 150 keV/μm范围内不依赖于电离密度。