D'Ardia Angela, Ciliberti Valeria, Zeppa Pio, Caputo Alessandro
University of Salerno - Baronissi Campus: Universita degli Studi di Salerno, Campus Baronissi Via Allende Baronissi (SA), Salerno, Italy.
Leuk Res Rep. 2022 Apr 13;17:100316. doi: 10.1016/j.lrr.2022.100316. eCollection 2022.
Light-chain restricted hematogones (LCR HGs) detected by flow cytometry (FC) may, occur in bone marrow mimicking involvement by a B-cell lymphoma. This phenomenon can present a diagnostic pitfall and negatively impact patient management, and may occur in other organs, including lymph nodes, For this reason, it is recommended to utilize, in case of LCR in lymph node, one additional morphological, phenotypical or molecular criteria for the diagnosis of lymphoma on cytological samples.
通过流式细胞术（FC）检测到的轻链限制性造血前体细胞（LCR HGs）可能在骨髓中出现，类似B细胞淋巴瘤的浸润。这种现象可能导致诊断陷阱并对患者管理产生负面影响，并且可能发生在包括淋巴结在内的其他器官中。因此，对于淋巴结中出现LCR的情况，建议在细胞学样本上采用一项额外的形态学、表型或分子标准来诊断淋巴瘤。
