Rare evolution of -mutated chronic neutrophilic leukemia to t(4;12)(q12;p13) acute myeloid leukemia with mutation.

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disease accompanied by mutations in . Here, we present a patient with CNL who developed to acute myeloid leukemia (AML) at the same time that a t(4;12)(q12;p13) translocation appeared. The uniqueness of this cytogenetic abnormality led us to delineate the molecular aberrations relevant for clonal evolution. While the mutation was present throughout the course of the disease, the mutation was newly acquired at the AML transformation. The present case suggests that careful monitoring of t(4;12)(q12;p13) and is crucial to predict AML evolution in CNL patients.