Asadi Sara, Aminianfar Azadeh, Shiva Fahimeh, Asadi Sasan, Yarizadeh Habib, Qorbani Mostafa, Mirzaei Khadijeh
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Evid Based Complement Alternat Med. 2022 Apr 21;2022:2661649. doi: 10.1155/2022/2661649. eCollection 2022.
Diabetes sensorimotor polyneuropathy (DSPN) is a common complication of diabetes. Diet has been previously related to DSPN. However, no studies have investigated the relationship between the inflammatory potential of the whole diet and DSPN. So, we aimed to examine the association between dietary inflammatory index (DII) and DSPN in Iranian adults.
A total of 185 subjects with DSPN and 185 sex- and age-matched controls were selected in this case-control study. A 168-item validated food frequency questionnaire (FFQ) was used to assay dietary intakes. DII was calculated based on the developed formula. The Toronto clinical neuropathy score was applied to define DSPN. Binary logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (95% CIs) of DII in relation to DSPN.
Mean values of age and BMI for all the participants were reported as 50.79 and 28.60, respectively. Also, the median (IQR) of DII for all the participants was estimated as -0.091 (-0.93, 1.07). Our findings suggest that participants in the highest quartile of the DII had higher odds of DSPN (OR = 1.76; 95% CI: 1.03, 3.36) (-trend = 0.01) compared to subjects in the lowest quartile of DII scores after adjustment for age and sex. Additionally, a strong association was observed after adjusting for energy intake, physical activity, education, smoking status, economic status, marital status, job, BMI, and WC in model 2 (OR = 2.23, 95% CI = 1.13-4.39) (-trend = 0.0048).
Higher DII score was associated with an increased risk of DSPN. Therefore, it is possible that a diet rich in anti-inflammatory nutrients and foods could improve and prevent DSPN.
糖尿病感觉运动性多发性神经病变（DSPN）是糖尿病常见的并发症。以往研究表明饮食与DSPN有关。然而，尚无研究探讨整体饮食的炎症潜力与DSPN之间的关系。因此，我们旨在研究伊朗成年人饮食炎症指数（DII）与DSPN之间的关联。
在这项病例对照研究中，共选取了185例DSPN患者和185例年龄、性别匹配的对照。采用一份经过验证的包含168个条目的食物频率问卷（FFQ）来评估饮食摄入量。根据既定公式计算DII。采用多伦多临床神经病变评分来定义DSPN。使用二元逻辑回归来估计DII与DSPN相关的比值比（OR）和95%置信区间（95%CI）。
所有参与者的年龄均值和BMI分别为50.79和28.60。此外，所有参与者DII的中位数（四分位间距）估计为-0.091（-0.93，1.07）。我们的研究结果表明，在调整年龄和性别后，DII处于最高四分位数的参与者患DSPN的几率更高（OR = 1.76；95%CI：1.03，3.36）（-趋势 = 0.01），与DII得分处于最低四分位数的受试者相比。此外，在模型2中调整能量摄入、身体活动、教育程度、吸烟状况、经济状况、婚姻状况、工作、BMI和腰围后，观察到显著关联（OR = 2.23，95%CI = 1.13 - 4.39）（-趋势 = 0.0048）。
较高的DII得分与DSPN风险增加相关。因此，富含抗炎营养素和食物的饮食有可能改善和预防DSPN。
