非编码 RNA 作为脑血管病的诊断和预后生物标志物。
Noncoding RNA as Diagnostic and Prognostic Biomarkers in Cerebrovascular Disease.
机构信息
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China.
Neurosurgical Institute of Fudan University, China.
出版信息
Oxid Med Cell Longev. 2022 Apr 19;2022:8149701. doi: 10.1155/2022/8149701. eCollection 2022.
Noncoding RNAs (ncRNAs), such as microRNAs, long noncoding RNAs, and circular RNAs, play an important role in the pathophysiology of cerebrovascular diseases (CVDs). They are effectively detectable in body fluids, potentially suggesting new biomarkers for the early detection and prognosis of CVDs. In this review, the physiological functions of circulating ncRNAs and their potential role as diagnostic and prognostic markers in patients with cerebrovascular diseases are discussed, especially in acute ischemic stroke, subarachnoid hemorrhage, and moyamoya disease.
非编码 RNA（ncRNA），如 microRNA、长非编码 RNA 和环状 RNA，在脑血管疾病（CVD）的病理生理学中发挥着重要作用。它们在体液中可有效检测到，可能为 CVD 的早期检测和预后提供新的生物标志物。在这篇综述中，讨论了循环 ncRNA 的生理功能及其作为脑血管疾病患者诊断和预后标志物的潜在作用，特别是在急性缺血性脑卒中、蛛网膜下腔出血和烟雾病中。
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