• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

他克莫司治疗药物水平导致肾移植患者颅内出血。

Therapeutic drug level of tacrolimus causing intracranial hemorrhage in a patient with renal transplant.

作者信息

Shah Sangam, Ojha Rajeev, Chamlagain Rajan, Chhetri Santosh, Prasad Pravin, Baral Bikash, Gyawali Bindu, Shrestha Ashish, Yadav Jayant Kumar

机构信息

Maharajgunj Medical Campus Institute of Medicine Tribhuvan University Maharajgunj Nepal.

Department of Internal Medicine Institute of Medicine Tribhuvan University Maharajgunj Nepal.

出版信息

Clin Case Rep. 2022 Apr 26;10(4):e05788. doi: 10.1002/ccr3.5788. eCollection 2022 Apr.

DOI:10.1002/ccr3.5788
PMID:35498342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043708/
Abstract

Tacrolimus is used in solid organ transplant patients to prevent rejection, and no case of intracerebral hemorrhage (ICH) has been reported till date. We report a case of 31-year-old man with diabetes and hypertension for ten years who had a renal transplant four years back; diagnosed with tacrolimus-induced ICH.

摘要

他克莫司用于实体器官移植患者以预防排斥反应，迄今为止尚未有脑出血（ICH）的病例报告。我们报告一例31岁男性患者，患有糖尿病和高血压10年，4年前接受了肾移植；诊断为他克莫司诱发的脑出血。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7480/9043708/7714614434dc/CCR3-10-e05788-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7480/9043708/7714614434dc/CCR3-10-e05788-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7480/9043708/7714614434dc/CCR3-10-e05788-g001.jpg

相似文献

1
Therapeutic drug level of tacrolimus causing intracranial hemorrhage in a patient with renal transplant.他克莫司治疗药物水平导致肾移植患者颅内出血。
Clin Case Rep. 2022 Apr 26;10(4):e05788. doi: 10.1002/ccr3.5788. eCollection 2022 Apr.
2
Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients.两名器官移植受者中免疫抑制剂所致回肠溃疡的成功治疗
World J Gastroenterol. 2016 Jun 28;22(24):5616-22. doi: 10.3748/wjg.v22.i24.5616.
3
Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient.病例报告：一名肾移植患者中波尔多树（Peumus boldus）与他克莫司的相互作用。
Transplant Proc. 2014 Sep;46(7):2400-2. doi: 10.1016/j.transproceed.2014.01.021. Epub 2014 Jun 27.
4
Tacrolimus: a further update of its use in the management of organ transplantation.他克莫司：其在器官移植管理中应用的进一步更新
Drugs. 2003;63(12):1247-97. doi: 10.2165/00003495-200363120-00006.
5
Tacrolimus in transplant rejection.他克莫司在移植排斥中的应用。
Expert Opin Pharmacother. 2013 Jan;14(1):115-22. doi: 10.1517/14656566.2013.751374. Epub 2012 Dec 10.
6
Tacrolimus: the good, the bad, and the ugly.他克莫司：优点、缺点与不足
Pediatr Transplant. 2001 Feb;5(1):32-6. doi: 10.1034/j.1399-3046.2001.00025.x.
7
Smooth muscle-specific actin levels in the urine of renal transplant recipients: correlation with cyclosporine or tacrolimus nephrotoxicity.肾移植受者尿液中平滑肌特异性肌动蛋白水平：与环孢素或他克莫司肾毒性的相关性。
Am J Kidney Dis. 1999 Jul;34(1):69-84. doi: 10.1016/s0272-6386(99)70111-3.
8
A multicenter trial of FK506 (tacrolimus) therapy in refractory acute renal allograft rejection. A report of the Tacrolimus Kidney Transplantation Rescue Study Group.FK506（他克莫司）治疗难治性急性肾移植排斥反应的多中心试验。他克莫司肾移植挽救研究组报告。
Transplantation. 1996 Sep 15;62(5):594-9. doi: 10.1097/00007890-199609150-00009.
9
Acute tacrolimus toxicity in a non-transplant patient.一名非移植患者的急性他克莫司中毒
Clin Toxicol (Phila). 2008 Nov;46(9):838-40. doi: 10.1080/15563650801898528.
10
Dilated Cardiomyopathy in an Adult Renal Transplant Recipient: Recovery Upon Tacrolimus to Sirolimus Switch: A Case Report.成人肾移植受者扩张型心肌病：他克莫司转换为西罗莫司后恢复：病例报告。
Transplant Proc. 2020 Nov;52(9):2758-2761. doi: 10.1016/j.transproceed.2020.06.011. Epub 2020 Jul 20.

引用本文的文献

1
The Collapse of Brain Clearance: Glymphatic-Venous Failure, Aquaporin-4 Breakdown, and AI-Empowered Precision Neurotherapeutics in Intracranial Hypertension.脑清除功能的崩溃：颅内高压中的淋巴-静脉功能衰竭、水通道蛋白4的破坏以及人工智能助力的精准神经治疗
Int J Mol Sci. 2025 Jul 25;26(15):7223. doi: 10.3390/ijms26157223.
2
Tacrolimus-Associated Cerebral Vasculopathy Presenting with Recurrent Intracerebral Hemorrhage.与他克莫司相关的脑血管病伴复发性脑出血
Indian J Nephrol. 2023 Sep-Oct;33(5):398-399. doi: 10.4103/ijn.ijn_281_22. Epub 2023 Apr 4.

本文引用的文献

1
Blood Pressure and Outcomes in Patients With Different Etiologies of Intracerebral Hemorrhage: A Multicenter Cohort Study.不同病因脑出血患者的血压与结局：一项多中心队列研究。
J Am Heart Assoc. 2020 Oct 20;9(19):e016766. doi: 10.1161/JAHA.120.016766. Epub 2020 Sep 13.
2
Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review.中枢神经系统单纯疱疹病毒感染的脑血管表现：系统评价。
J Neuroinflammation. 2019 Jan 29;16(1):19. doi: 10.1186/s12974-019-1409-4.
3
Cancer-associated stroke: Pathophysiology, detection and management (Review).
癌症相关性卒中：病理生理学、检测与管理（综述）。
Int J Oncol. 2019 Mar;54(3):779-796. doi: 10.3892/ijo.2019.4669. Epub 2019 Jan 2.
4
Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling.钙调神经磷酸酶抑制剂环孢素 A 和他克莫司通过 TLR4 信号诱导血管炎症和内皮细胞活化。
Sci Rep. 2016 Jun 13;6:27915. doi: 10.1038/srep27915.
5
Susceptibility weighted imaging: An important tool for early diagnosis of tacrolimus toxicity.磁敏感加权成像：他克莫司毒性早期诊断的重要工具。
Indian J Nephrol. 2016 Mar-Apr;26(2):151-2. doi: 10.4103/0971-4065.156908.
6
Everolimus-based calcineurin-inhibitor sparing regimens for kidney transplant recipients: a systematic review and meta-analysis.基于依维莫司的肾移植受者钙调神经磷酸酶抑制剂减量方案：一项系统评价和荟萃分析。
Int Urol Nephrol. 2014 Oct;46(10):2035-44. doi: 10.1007/s11255-014-0783-1. Epub 2014 Jul 16.
7
The association between cerebral developmental venous anomaly and concomitant cavernous malformation: an observational study using magnetic resonance imaging.脑发育性静脉异常与伴发海绵状血管畸形的相关性：一项磁共振成像观察性研究。
BMC Neurol. 2014 Mar 15;14:50. doi: 10.1186/1471-2377-14-50.
8
Tacrolimus-related cerebral microbleeds after lung transplantation.肺移植术后与他克莫司相关的脑微出血
Case Rep Transplant. 2013;2013:708961. doi: 10.1155/2013/708961. Epub 2013 Dec 2.
9
Cerebrospinal fluid analyses for the diagnosis of subarachnoid haemorrhage and experience from a Swedish study. What method is preferable when diagnosing a subarachnoid haemorrhage?脑脊液分析在蛛网膜下腔出血诊断中的应用及瑞典研究经验。蛛网膜下腔出血的诊断中哪种方法更可取？
Clin Chem Lab Med. 2013 Nov;51(11):2073-86. doi: 10.1515/cclm-2012-0783.
10
Posterior reversible encephalopathy syndrome and hemorrhage associated with tacrolimus in a pediatric heart transplantation recipient.一名小儿心脏移植受者中与他克莫司相关的后部可逆性脑病综合征和出血
Pediatr Transplant. 2013 Mar;17(2):E67-70. doi: 10.1111/petr.12039. Epub 2013 Jan 17.