Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Chongwen District, Beijing 100050, People's Republic of China.
BMC Neurol. 2014 Mar 15;14:50. doi: 10.1186/1471-2377-14-50.
Some studies reported that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But there is lack of statistical evidence and study of bulk cases. The factors associated with concurrency are still unknown. The purpose of this study was to determine the prevalence of concomitant DVA and CM using observational data on Chinese patients and analyze the factors associated with the concurrency.
The records of all cranial magnetic resonance imaging (MRI) performed between January 2001 and December 2012 in Beijing Tiantan Hospital were reviewed retrospectively. The DVA and CM cases were selected according to imaging reports that met diagnostic criteria. Statistical analysis was performed using the Pearson chi-square statistic for binary variables and multivariable logistic regression analysis for predictors associated with the concurrent CM.
We reviewed a total of 165,230 cranial MR images performed during the previous 12 year period, and identified 1,839 cases that met DVA radiographic criteria. There were 205 patients who presented concomitant CM among the 1,839 DVAs. The CM prevalence in DVA cases (11.1%) was significantly higher than that in the non-DVA cases (2.3%) (P<0.01). In the multivariate analysis, we found that DVAs with three or more medullary veins in the same MRI section (adjusted OR = 2.37, 95% CI: 1.73-3.24), infratentorial DVAs (adjusted OR = 1.71, 95% CI: 1.26-2.33) and multiple DVAs (adjusted OR = 2.08, 95% CI: 1.04-4.16) have a higher likelihood of being concomitant with CM.
CM are prone to coexisting with DVA. There is a higher chance of concurrent CM with DVA when the DVA has three or more medullary veins in the same MRI scanning section, when the DVA is infratentorial, and when there are multiple DVAs. When diagnosing DVA cases, physicians should be alerted to the possibility of concurrent CM.
一些研究报道脑发育性静脉异常（DVA）常与海绵状血管畸形（CM）并存。但缺乏统计学证据和大宗病例研究。与并存相关的因素尚不清楚。本研究的目的是使用中国患者的观察性数据确定并发 DVA 和 CM 的患病率，并分析与并存相关的因素。
回顾性分析 2001 年 1 月至 2012 年 12 月期间在北京天坛医院进行的所有头颅磁共振成像（MRI）的记录。根据符合诊断标准的影像学报告选择 DVA 和 CM 病例。采用二项变量的 Pearson 卡方检验和与并发 CM 相关的预测因子的多变量逻辑回归分析进行统计分析。
我们回顾了过去 12 年期间进行的 165230 例头颅 MRI，共发现符合 DVA 影像学标准的 1839 例。在 1839 例 DVA 中，有 205 例患者同时存在 CM。DVA 病例中 CM 的患病率（11.1%）明显高于非 DVA 病例（2.3%）（P<0.01）。在多变量分析中，我们发现同一 MRI 节段有 3 条或以上髓静脉的 DVA（调整后 OR=2.37，95%CI：1.73-3.24）、幕下 DVA（调整后 OR=1.71，95%CI：1.26-2.33）和多发 DVA（调整后 OR=2.08，95%CI：1.04-4.16）更有可能并发 CM。
CM 易与 DVA 并存。当 DVA 在同一 MRI 扫描节段有 3 条或以上髓静脉、DVA 幕下和多发 DVA 时，并发 CM 的可能性更高。在诊断 DVA 病例时，医生应警惕并发 CM 的可能性。
