Tu Lu, Zhao Jingjie, Chen Qiuyang, Zhang Shan, Liang Lin, Tang Xinming, Hou Shaohua, Yang Weifang, Liang Ruiying
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Beijing General Station of Animal Husbandry, Beijing, China.
Front Vet Sci. 2022 Apr 14;9:857834. doi: 10.3389/fvets.2022.857834. eCollection 2022.
Pseudorabies virus (PRV) is a zoonotic agent that causes significant economic losses in animal husbandry worldwide, and -deleted vaccines play an important role in its treatment in the swine industry. However, the potential risk of attenuated PRV strains in commercial vaccines for other hosts remains unclear. Especially, cats are important companion animals for human beings. In this study, we investigated the prevalence and pathogenicity of the PRV wild strain in the cat population. We found that the occurrence of PR diseases in cats is sporadic, that the attenuated PRV strain causes slight clinical signs in cats, and that the virus is excreted 3 days post-infection. Our findings will be beneficial in furthering our understanding of the epidemiology and pathogenicity of PRV in cats and implying the great risk of RPV transmission from pigs to cats.
伪狂犬病病毒（PRV）是一种人畜共患病原体，在全球畜牧业中造成重大经济损失，而基因缺失疫苗在猪产业的治疗中发挥着重要作用。然而，商业疫苗中减毒PRV毒株对其他宿主的潜在风险仍不明确。特别是，猫是人类重要的伴侣动物。在本研究中，我们调查了PRV野生毒株在猫群体中的流行情况和致病性。我们发现猫中PR疾病的发生是散发性的，减毒PRV毒株在猫中引起轻微临床症状，并且该病毒在感染后3天排出。我们的研究结果将有助于进一步了解PRV在猫中的流行病学和致病性，并暗示PRV从猪传播到猫的巨大风险。
