Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, College of Animal Science, South China Agricultural University, Guangzhou 510642, PR China.
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.
Vet Microbiol. 2020 Dec;251:108912. doi: 10.1016/j.vetmic.2020.108912. Epub 2020 Nov 1.
Pseudorabies virus (PRV) is a zoonotic agent with a wide host range, causing significant economic losses in animal husbandry and potential public health risk globally. The causative agent has recently gained attention due to the inter-species transmission among different species of animals, even human beings. Although PRV's prevalence is found in many species of animals, regardless of whether the strain involved is a vaccine, classical or variant, few lines of evidence for the viral transmission route are available. Here, we reported that viral contamination is associated with the inter-species transmission of PRV. We found that PRV contamination was widely distributed in the environment of pig farms, that viral distribution in the environment is associated with the implementation of biosecurity measures, and that PRV could transmit from pigs to dogs through virally contaminated fomites. Collectively, our findings provide a basis for understanding the ecology and transmission route of PRV and underscore the importance of implementing biosecurity measures to control this disease.
伪狂犬病病毒（PRV）是一种具有广泛宿主范围的人畜共患病病原体，在全球范围内给畜牧业造成了重大的经济损失，并存在潜在的公共卫生风险。由于该病原体在不同动物物种之间甚至在人类之间发生了种间传播，因此最近受到了关注。尽管 PRV 在许多动物物种中都有流行，但无论涉及的毒株是疫苗株、经典株还是变异株，关于病毒传播途径的证据都很少。在这里，我们报告了病毒污染与 PRV 的种间传播有关。我们发现 PRV 污染广泛分布在猪场环境中，病毒在环境中的分布与生物安全措施的实施有关，并且 PRV 可以通过受病毒污染的媒介从猪传播给狗。总之，我们的研究结果为了解 PRV 的生态学和传播途径提供了依据，并强调了实施生物安全措施来控制这种疾病的重要性。
