莫汉吉酸C提议结构的合成

Synthesis of the Proposed Structure of Mohangic Acid C.

作者信息

Takahashi Keisuke, Kudo Shunya, Kawamura Kiharu, Kusakabe Taichi, Kikkawa Shoko, Azumaya Isao, Kato Keisuke

机构信息

Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.

出版信息

Org Lett. 2022 May 13;24(18):3416-3420. doi: 10.1021/acs.orglett.2c01285. Epub 2022 May 2.

DOI:10.1021/acs.orglett.2c01285

PMID:35499310

Abstract

The proposed structure of mohangic acid C () was stereoselectively synthesized via a catalytic asymmetric aldol reaction to install a -aminoacetophenone moiety, Marshall propargylation furnishing two stereocenters, and Cu-mediated Stille-type coupling to construct the whole framework of .

摘要

通过催化不对称羟醛反应立体选择性地合成了莫汉吉酸C（）的提议结构，以引入α-氨基苯乙酮部分，马歇尔炔丙基化形成两个立体中心，以及铜介导的Stille型偶联反应来构建其整个骨架。