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横纹肌肉瘤罕见新生儿病例的组织病理学分析和分子遗传学的重要性。

Importance of histopathological analysis and molecular genetics in a rare neonatal case of rhabdomyosarcoma.

机构信息

Gold Coast University Hospital, Southport, Queensland, Australia.

Queensland Children's Hospital, University of Queensland, South Brisbane, Queensland, Australia.

出版信息

Australas J Dermatol. 2022 Aug;63(3):380-384. doi: 10.1111/ajd.13849. Epub 2022 May 2.

DOI:10.1111/ajd.13849
PMID:35500145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9540745/
Abstract

We present a case of a neonate who presented with multiple cutaneous and subcutaneous nodules, which was found to be metastatic embryonal rhabdomyosarcoma. Rhabdomyosarcoma is a soft tissue malignancy that usually occurs in children aged one to five but is rare in neonates. The histopathological analysis and molecular genetics are important in the classification of subtype and in guiding treatment options and informing prognosis.

摘要

我们报告了一例新生儿病例，其表现为多个皮肤和皮下结节，被诊断为转移性胚胎性横纹肌肉瘤。横纹肌肉瘤是一种软组织恶性肿瘤，通常发生在 1 至 5 岁的儿童中，但在新生儿中很少见。组织病理学分析和分子遗传学在亚型分类、指导治疗选择和预后方面具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/01d43a282866/AJD-63-380-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/2af9b81f96b2/AJD-63-380-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/2955444df3e4/AJD-63-380-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/01d43a282866/AJD-63-380-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/2af9b81f96b2/AJD-63-380-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/2955444df3e4/AJD-63-380-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b96/9540745/01d43a282866/AJD-63-380-g001.jpg

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本文引用的文献

1
Evolving classification of rhabdomyosarcoma.横纹肌肉瘤的分类演变。
Histopathology. 2022 Jan;80(1):98-108. doi: 10.1111/his.14449.
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Pathology of childhood rhabdomyosarcoma: A consensus opinion document from the Children's Oncology Group, European Paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.儿童横纹肌肉瘤的病理学：来自儿童肿瘤学组、欧洲儿科软组织肉瘤研究组和软组织肉瘤合作研究组的共识意见文件。
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Cancer. 2011 Aug 1;117(15):3493-501. doi: 10.1002/cncr.25887. Epub 2011 Jan 24.
8
Congenital primary cutaneous rhabdomyosarcoma in a neonate.新生儿先天性原发性皮肤横纹肌肉瘤
Pediatr Dermatol. 2003 Jul-Aug;20(4):335-8. doi: 10.1046/j.1525-1470.2003.20413.x.
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Pathologic classification of rhabdomyosarcomas and correlations with molecular studies.横纹肌肉瘤的病理分类及其与分子研究的相关性
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The Third Intergroup Rhabdomyosarcoma Study.第三项横纹肌肉瘤多组协作研究
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