横纹肌肉瘤的分类演变。
Evolving classification of rhabdomyosarcoma.
机构信息
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Histopathology. 2022 Jan;80(1):98-108. doi: 10.1111/his.14449.
Abstract
Rhabdomyosarcomas comprise the single largest category of soft tissue sarcomas in children and adolescents in the United States, occurring in 4.5 million people aged below 20 years. Based on the clinicopathological features and genetic abnormalities identified, rhabdomyosarcomas are classified into embryonal, alveolar, spindle cell/sclerosing and pleomorphic subtypes. Each subtype shows distinctive morphology and has characteristic genetic abnormalities. This review discusses the evolution of the classification of rhabdomyosarcoma to the present day, together with a discussion of key histomorphological and genetic features of each subtype and the diagnostic approach to these tumours.
摘要
横纹肌肉瘤构成了美国儿童和青少年中软组织肉瘤的单一最大类别，在年龄低于 20 岁的人群中发生于 450 万人。基于鉴定出的临床病理特征和遗传异常，横纹肌肉瘤被分为胚胎性、肺泡性、梭形细胞/硬化性和多形性亚型。每种亚型都表现出独特的形态学特征，并具有特征性的遗传异常。这篇综述讨论了横纹肌肉瘤分类的发展演变至今，以及每个亚型的关键组织形态学和遗传学特征的讨论，以及这些肿瘤的诊断方法。
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