Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands.
Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands; Pro Persona Mental Health Care, Depression Expertise Centre, Nijmegen, The Netherlands.
Psychiatry Res Neuroimaging. 2022 Jul;323:111481. doi: 10.1016/j.pscychresns.2022.111481. Epub 2022 Apr 12.
Self-referent negative memory bias is a known risk factor for depression, but recent evidence suggests its function as a transdiagnostic cognitive depressotypic marker. The amygdala's sensitivity for negative information is considered a neurobiological depressotypic marker. However, their relationship remains unknown. We transdiagnostically investigated the association between the amygdala's sensitivity, self-referent negative memory bias and its two components: negative endorsement bias and negative recall bias. Patients (n= 125) with (multimorbid) stress-related and neurodevelopmental psychiatric disorders and healthy controls (n= 78) performed an fMRI task to assess the amygdala's sensitivity for negative information and a task outside the scanner for the biases. Linear regression models assessed their associations. The left amygdala's sensitivity for negative information was significantly positively associated with negative recall bias in patients, but not controls. There were no significant associations with self-referent negative memory bias or negative endorsement bias or between the two depressotypic markers. Thus, the left amygdala's sensitivity for negative information may be considered a neural marker of negative memory bias across psychiatric diagnoses. Further research on the interactons with known determinants such as genetic predisposition is required to fully understand the relationship between the amygdala's sensitivity for negative information and these biases.
自我参照负性记忆偏向是抑郁的已知风险因素，但最近的证据表明，它作为一种跨诊断认知抑郁表型标志物的功能。杏仁核对负性信息的敏感性被认为是一种神经生物学抑郁表型标志物。然而，它们之间的关系尚不清楚。我们跨诊断地研究了杏仁核敏感性、自我参照负性记忆偏向及其两个组成部分（负性评价偏向和负性回忆偏向）之间的关联。患者（n=125）患有（多病因）与压力相关的和神经发育性精神障碍，健康对照组（n=78）进行了 fMRI 任务以评估杏仁核对负性信息的敏感性，以及在扫描仪外进行了任务以评估偏向。线性回归模型评估了它们之间的关联。在患者中，左杏仁核对负性信息的敏感性与负性回忆偏向显著正相关，但在对照组中则没有显著关联。与自我参照负性记忆偏向或负性评价偏向或两个抑郁表型标志物之间均无显著关联。因此，左杏仁核对负性信息的敏感性可以被认为是跨精神障碍诊断的负性记忆偏向的神经生物学标志物。需要进一步研究与遗传易感性等已知决定因素的相互作用，以充分理解杏仁核对负性信息的敏感性与这些偏向之间的关系。
