一项前瞻性研究评估了在射频消融治疗有症状的良性甲状腺结节时使用低剂量静脉镇静和镇痛的效果。

A prospective study evaluating the use of low-dose intravenous sedation and analgesia during radiofrequency ablation of symptomatic, benign thyroid nodules.

机构信息

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

出版信息

Am J Surg. 2022 Sep;224(3):928-931. doi: 10.1016/j.amjsurg.2022.04.020. Epub 2022 Apr 26.

DOI:10.1016/j.amjsurg.2022.04.020

Abstract

BACKGROUND

We compared post-treatment pain, quality of recovery and complications between those who did not receive (Group I) and received (Group II) intravenous low-dose Midazolam (<0.05 mg/kg) and Pethidine (<0.5 mg/kg) during radiofrequency ablation (RFA) of benign thyroid nodules.

METHODS

Both groups received local anesthesia. Post-treatment pain was rated by a 0-10 numerical rating scale (NRS). The Quality-of-Recovery-9 (QoR9) questionnaire was completed upon discharge.

RESULTS

Each group included 25 patients. Baseline characteristics were comparable (p > 0.05). Group II had lower pain NRS than group I both immediately (0 (0-3.5) vs. 4 (3-5), p = 0.002) and 4 h after RFA (2 (0.5-4) vs 3.5 (2-5), p = 0.031). There were no differences in complications and QoR9 score (Group I: 15 (13-17) vs Group II: 16 (14-18), p = 0.254). Both groups were discharged within the same day.

CONCLUSION

Low dose intravenous sedation improved pain control without affecting recovery or safety in thyroid RFA.

摘要

背景

我们比较了在良性甲状腺结节射频消融（RFA）期间未接受（I 组）和接受（II 组）静脉注射小剂量咪达唑仑（<0.05mg/kg）和哌替啶（<0.5mg/kg）治疗的患者的治疗后疼痛、恢复质量和并发症。

方法

两组均接受局部麻醉。治疗后疼痛采用 0-10 数字评分量表（NRS）进行评分。出院时完成 QoR9 问卷。

结果

每组各 25 例患者。基线特征无差异（p>0.05）。即刻（0（0-3.5）vs. 4（3-5），p=0.002）和 RFA 后 4 小时（2（0.5-4）vs. 3.5（2-5），p=0.031），II 组的疼痛 NRS 评分均低于 I 组。两组并发症和 QoR9 评分无差异（I 组：15（13-17）vs. II 组：16（14-18），p=0.254）。两组均在同一天出院。