Division of Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Division of Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Trends Immunol. 2022 Jun;43(6):478-495. doi: 10.1016/j.it.2022.04.002. Epub 2022 Apr 29.
Despite an ever-increasing appreciation of how protein-coding genes shape immune responses, the molecular underpinnings of immune regulation remain incompletely understood. This incomplete picture impedes the development of more precise therapeutics and diagnostics for immune-mediated diseases. Long noncoding RNAs (lncRNAs) are versatile cell- and context-specific regulators of gene expression and cellular function. The number of lncRNA genes rivals that of protein-coding genes; however, comparatively little is known about their function. Even though the functions of most lncRNA genes are unknown, multiple lncRNAs have recently emerged as important immune regulators. Therefore, further unlocking the role of lncRNAs in the mammalian immune system coupled with their tissue-specific expression might lead to more precise therapeutics and diagnostics for immune disorders in general.
尽管人们越来越了解蛋白质编码基因如何塑造免疫反应，但免疫调节的分子基础仍不完全清楚。这种不完整的认识阻碍了针对免疫介导疾病的更精确治疗和诊断方法的发展。长非编码 RNA（lncRNA）是细胞和上下文特异性基因表达和细胞功能的多功能调节剂。lncRNA 基因的数量与蛋白质编码基因相当；然而，关于它们的功能知之甚少。尽管大多数 lncRNA 基因的功能尚不清楚，但最近有多种 lncRNA 已成为重要的免疫调节剂。因此，进一步揭示 lncRNA 在哺乳动物免疫系统中的作用及其组织特异性表达可能会导致针对一般免疫紊乱的更精确治疗和诊断。
