Research Service, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
Department of Physical Therapy, University of Florida, Gainesville, FL, USA.
Spinal Cord Ser Cases. 2022 Apr 30;8(1):49. doi: 10.1038/s41394-022-00515-9.
Observational, analytical cohort study.
After incomplete spinal cord injury (iSCI), propriospinal pathways may remain intact enabling coupling between respiration and locomotion. This locomotor-respiratory coupling (LRC) may enable coordination between these two important behaviors and have implications for rehabilitation after iSCI. However, coordination between these behaviors is not well understood and it is unknown if iSCI disrupts LRC. The objective of this study was to compare LRC in ambulatory adults with iSCI to able-bodied controls.
Rehabilitation Research Center, Jacksonville, Florida, United States of America.
Adults with iSCI (4 males, 1 female) and able-bodied controls (2 males, 3 females) walked at their fastest comfortable speed for 6 min over ground, and on a treadmill with bodyweight support (10-20%) and as-needed assistance at a standardized fast speed (controls) or their fastest speed (iSCI) for 6 min. LRC was quantified as the percent of breaths that were coupled with steps at a consistent ratio during the last 4 min of each walking condition.
Over ground, participants with iSCI demonstrated significantly more LRC than able-bodied controls (72.4 ± 6.4% vs. 59.1% ± 7.5, p = 0.016). During treadmill walking, LRC did not differ between groups (iSCI 67.5 ± 15.8% vs. controls 66.3 ± 4.0%, p > 0.05).
Adults with iSCI demonstrated similar or greater LRC compared to able-bodied controls. This suggests that pathways subserving coordination between these behaviors remain intact in this group of individuals who walk independently after iSCI.
观察性、分析性队列研究。
不完全性脊髓损伤（iSCI）后，本体感觉通路可能保持完整，从而实现呼吸与运动的耦合。这种运动-呼吸耦合（LRC）可能使这两种重要行为协调，并对 iSCI 后的康复产生影响。然而，这些行为的协调尚不清楚，也不知道 iSCI 是否会破坏 LRC。本研究的目的是比较 iSCI 后能行走的成年人与健全对照组的 LRC。
美国佛罗里达州杰克逊维尔康复研究中心。
iSCI 患者（4 名男性，1 名女性）和健全对照组（2 名男性，3 名女性）在地面上以最快舒适的速度行走 6 分钟，在跑步机上以 10-20%的体重支持和按需协助以标准化的快速速度（对照组）或他们的最快速度（iSCI）行走 6 分钟。LRC 是通过在每个行走条件的最后 4 分钟内将呼吸与步幅以一致的比例耦合的呼吸百分比来量化的。
在地面上，iSCI 患者的 LRC 明显高于健全对照组（72.4%±6.4% vs. 59.1%±7.5%，p=0.016）。在跑步机行走时，两组之间的 LRC 没有差异（iSCI 67.5%±15.8% vs. 对照组 66.3%±4.0%，p>0.05）。
iSCI 后的成年人表现出与健全对照组相似或更高的 LRC。这表明，在这群能够独立行走的个体中，协调这些行为的通路在损伤后仍然完整。
