Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, 1117, Hungary.
Biol Futur. 2022 Jun;73(2):171-185. doi: 10.1007/s42977-022-00120-9. Epub 2022 May 2.
In this review, we present recent scientific advances about integrin trafficking in the endo-lysosomal system. In the last few years, plenty of new information has emerged about the endo-lysosomal system, integrins, and the mechanism, how exactly the intracellular trafficking of integrins is regulated. We review the internalization and recycling pathways of integrins, and we provide information about the possible ways of lysosomal degradation through the endosomal and autophagic system. The regulation of integrin internalization and recycling proved to be a complex process worth studying. Trafficking of integrins, together with the regulation of their gene expression, defines cellular adhesion and cellular migration through bidirectional signalization and ligand binding. Thus, any malfunction in this system can potentially (but not necessarily) lead to tumorigenesis or metastasis. Hence, extensive examinations of integrins in the endo-lysosomal system raise the possibility to identify potential new medical targets. Furthermore, this knowledge can also serve as a basis for further determination of integrin signaling- and adhesion-related processes.
在这篇综述中，我们介绍了整合素在内体溶酶体系统中运输的最新科学进展。在过去的几年中，关于内体溶酶体系统、整合素以及整合素细胞内运输的确切调控机制，出现了大量新信息。我们回顾了整合素的内化和回收途径，并提供了有关通过内体和自噬系统进行溶酶体降解的可能途径的信息。整合素内化和回收的调控被证明是一个值得研究的复杂过程。整合素的运输，连同其基因表达的调控，通过双向信号转导和配体结合定义细胞黏附和细胞迁移。因此，该系统的任何功能障碍都可能（但不一定）导致肿瘤发生或转移。因此，对内体溶酶体系统中整合素的广泛研究有可能确定潜在的新医学靶点。此外，这些知识也可以作为进一步确定整合素信号转导和黏附相关过程的基础。
