实验性乳腺癌的早期诊断标志物和治疗靶点。
Early Diagnostic Markers and Therapeutic Targets for Experimental Breast Cancer.
机构信息
Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2022 Apr;172(6):747-751. doi: 10.1007/s10517-022-05470-x. Epub 2022 May 2.
Various stem cells were studied in female BALB/c mice at the early terms after administration of N-methyl-N-nitrosourea to search early diagnostic markers and therapeutic targets. At these terms, damage to the epithelium and endothelium, inflammation, and fibrosis were observed in the mammary gland, but the tumor was not detected. Cancer stem cells, hematopoietic stem cells (HSC), hematopoietic progenitor cells, angiogenic precursors, and epithelial progenitor cells were found in the blood and mammary gland. Cancer stem cells (CD44CD24) are proposed as the early diagnostic marker of breast cancer, and short-living HSC, hematopoietic progenitor cells, and angiogenic precursors (CD45-CD117FLK-1) as predictors of the formation of tumor microenvironment.
各种干细胞在雌性 BALB/c 小鼠给予 N-甲基-N-亚硝脲后早期进行研究，以寻找早期诊断标志物和治疗靶点。在这些时期，观察到乳腺的上皮和内皮损伤、炎症和纤维化，但未检测到肿瘤。在血液和乳腺中发现了癌症干细胞、造血干细胞（HSC）、造血祖细胞、血管生成前体细胞和上皮祖细胞。癌症干细胞（CD44CD24）被提出作为乳腺癌的早期诊断标志物，而短命的 HSC、造血祖细胞和血管生成前体细胞（CD45-CD117FLK-1）则作为肿瘤微环境形成的预测因子。
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