A. P. Avtsyn Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2022 Apr;172(6):765-769. doi: 10.1007/s10517-022-05474-7. Epub 2022 May 2.
We studied the expression of pluripotency factor Oct-4 and the intensity of apoptosis in the uterus during spontaneous and immune abortions in mice. Increased expression of factor Bax and reduced protein Bcl-2 synthesis in cells of the decidual membrane and decreased Oct-4 expression in the myometrium and perimetrium were detected. Thus, both spontaneous and immune-dependent abortions impair the apoptosis processes in the decidua and the formation of a pool of Oct-4 cells in the uterus. In immune-dependent abortions, the intensity of apoptosis of decidual cells was lower than in spontaneous abortion. Low expression of the transcription factor Oct-4 in the myometrium and perimetrium characterizes pregnancy failure irrespective of its mechanisms.
我们研究了多能性因子 Oct-4 的表达和在自发性和免疫性流产小鼠子宫中的细胞凋亡强度。在蜕膜细胞中检测到因子 Bax 的表达增加和蛋白 Bcl-2 合成减少，以及在子宫肌层和子宫旁组织中 Oct-4 表达降低。因此，自发性和免疫依赖性流产都会损害蜕膜中的细胞凋亡过程，并导致子宫中 Oct-4 细胞池的形成。在免疫依赖性流产中，蜕膜细胞的凋亡强度低于自发性流产。转录因子 Oct-4 在子宫肌层和子宫旁组织中的低表达特征是妊娠失败，无论其机制如何。
