Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Novosibirsk State University, Novosibirsk, 630090, Russia.
Biochemistry (Mosc). 2022 Jan;87(Suppl 1):S32-S0. doi: 10.1134/S0006297922140048.
Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability.
聚（ADP-核糖）化是蛋白质的一种翻译后修饰，在细胞对 DNA 损伤的反应中发挥着重要的调节功能。细胞中合成聚（ADP-核糖）（PAR）的关键酶是聚（ADP-核糖）聚合酶 1（PARP1）。了解 PARP1 活性在细胞内的调节机制对于开发 PARP1 靶向抗肿瘤治疗是必要的。本综述致力于研究 RNA 结合蛋白 YB-1 在 PARP1 催化的 PAR 化中的作用。YB-1 蛋白对 PARP1 活性的刺激机制可能扩展到其他参与维持基因组稳定性的 RNA 结合蛋白。
