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Poly(ADP-ribose) Polymerase 1 Modulates Interaction of the Nucleotide Excision Repair Factor XPC-RAD23B with DNA via Poly(ADP-ribosyl)ation.聚（ADP - 核糖）聚合酶1通过聚（ADP - 核糖基）化调节核苷酸切除修复因子XPC - RAD23B与DNA的相互作用。
J Biol Chem. 2015 Sep 4;290(36):21811-20. doi: 10.1074/jbc.M115.646638. Epub 2015 Jul 13.
2
Nucleotide excision repair factor XPC-RAD23B is poly(ADP-ribosylated) by the poly(ADP-ribose) polymerase 1.核苷酸切除修复因子XPC-RAD23B被聚（ADP-核糖）聚合酶1进行聚（ADP-核糖基）化修饰。
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3
Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1.聚（ADP-核糖基）化作为YB-1一种新的翻译后修饰
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4
[Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1].[聚（ADP-核糖）聚合酶1和2：经典功能以及与新的组蛋白聚（ADP-核糖基）化因子HPF1的相互作用]
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Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function.聚（ADP-核糖）介导的 XPA 和 PARP1 相互作用导致蛋白功能的相互调节。
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PARP1 is activated by membrane damage and is involved in membrane repair through poly(ADP-ribosyl)ation.聚腺苷二磷酸核糖聚合酶 1 （PARP1）可被膜损伤激活，并通过聚（ADP-核糖基）化参与膜修复。
Genes Cells. 2022 Apr;27(4):305-312. doi: 10.1111/gtc.12926. Epub 2022 Feb 21.
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Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins.聚（ADP-核糖）化由 PARP1 介导：反应机制和调节蛋白。
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Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.聚（ADP - 核糖基）化反应在细胞核功能调控中的作用
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PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.PARP1 通过稳定 DDB2 和募集 ALC1 促进核苷酸切除修复。
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Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1.Y 盒结合蛋白 1 对聚（ADP-核糖）聚合酶 1 活性的调节。
Biomolecules. 2020 Sep 16;10(9):1325. doi: 10.3390/biom10091325.

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Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks.解析聚（ADP-核糖）聚合酶1（PARP1）的锌离子与单链断裂和双链断裂结合的功能机制。
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本文引用的文献

1
Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function.聚（ADP-核糖）介导的 XPA 和 PARP1 相互作用导致蛋白功能的相互调节。
FEBS J. 2014 Aug;281(16):3625-41. doi: 10.1111/febs.12885. Epub 2014 Jul 21.
2
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.聚（ADP-核糖）糖苷酶对于从短暂复制应激中恢复并非必需，但在长期复制应激时对于防止聚（ADP-核糖）的有害积累是必需的。
Nucleic Acids Res. 2014 Jul;42(12):7776-92. doi: 10.1093/nar/gku505. Epub 2014 Jun 6.
3
Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites.鉴定 ADP-ribosylated 肽和 ADP-ribose 受体位点。
Front Biosci (Landmark Ed). 2014 Jun 1;19(7):1041-56. doi: 10.2741/4266.
4
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses.在不同的遗传毒性应激反应中对多聚（ADP-核糖）化靶标的蛋白质组学鉴定。
Mol Cell. 2013 Oct 24;52(2):272-85. doi: 10.1016/j.molcel.2013.08.026. Epub 2013 Sep 19.
5
Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome.针对天冬氨酸和谷氨酸 ADP-核糖基化蛋白质组的特异性研究。
Nat Methods. 2013 Oct;10(10):981-4. doi: 10.1038/nmeth.2603. Epub 2013 Aug 18.
6
Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.聚（ADP-核糖）聚合酶 1 在核苷酸切除修复中清除 UV 诱导的 DNA 损伤的作用。
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1658-63. doi: 10.1073/pnas.1209507110. Epub 2013 Jan 14.
7
PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.PARP1 通过稳定 DDB2 和募集 ALC1 促进核苷酸切除修复。
J Cell Biol. 2012 Oct 15;199(2):235-49. doi: 10.1083/jcb.201112132. Epub 2012 Oct 8.
8
Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.聚（ADP-核糖）有助于核苷酸切除修复中多聚（ADP-核糖）聚合酶 1 和着色性干皮病互补组 A 之间的关联。
J Biol Chem. 2012 Nov 16;287(47):39824-33. doi: 10.1074/jbc.M112.393504. Epub 2012 Oct 4.
9
DDB2 promotes chromatin decondensation at UV-induced DNA damage.DDB2 促进了 UV 诱导的 DNA 损伤处染色质的解凝聚。
J Cell Biol. 2012 Apr 16;197(2):267-81. doi: 10.1083/jcb.201106074. Epub 2012 Apr 9.
10
Photoactivated DNA analogs of substrates of the nucleotide excision repair system and their interaction with proteins of NER-competent extract of HeLa cells. Synthesis and application of long model DNA.光激活的核苷酸切除修复系统底物的 DNA 类似物及其与 HeLa 细胞 NER 有效提取物中蛋白质的相互作用。长模型 DNA 的合成与应用。
Biochemistry (Mosc). 2011 Jan;76(1):157-66. doi: 10.1134/s0006297911010159.

聚（ADP - 核糖）聚合酶1通过聚（ADP - 核糖基）化调节核苷酸切除修复因子XPC - RAD23B与DNA的相互作用。

Poly(ADP-ribose) Polymerase 1 Modulates Interaction of the Nucleotide Excision Repair Factor XPC-RAD23B with DNA via Poly(ADP-ribosyl)ation.

作者信息

Maltseva Ekaterina A, Rechkunova Nadejda I, Sukhanova Maria V, Lavrik Olga I

机构信息

From the Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentiev Ave., 630090 Novosibirsk and.

From the Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentiev Ave., 630090 Novosibirsk and the Department of Natural Sciences, Novosibirsk State University, 2 Pirogov St., 630090 Novosibirsk, Russia.

出版信息

J Biol Chem. 2015 Sep 4;290(36):21811-20. doi: 10.1074/jbc.M115.646638. Epub 2015 Jul 13.

DOI:10.1074/jbc.M115.646638
PMID:26170451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4571937/
Abstract

Poly(ADP-ribosyl)ation is a reversible post-translational modification that plays an essential role in many cellular processes, including regulation of DNA repair. Cellular DNA damage response by the synthesis of poly(ADP-ribose) (PAR) is mediated mainly by poly(ADP-ribose) polymerase 1 (PARP1). The XPC-RAD23B complex is one of the key factors of nucleotide excision repair participating in the primary DNA damage recognition. By using several biochemical approaches, we have analyzed the influence of PARP1 and PAR synthesis on the interaction of XPC-RAD23B with damaged DNA. Free PAR binds to XPC-RAD23B with an affinity that depends on the length of the poly(ADP-ribose) strand and competes with DNA for protein binding. Using (32)P-labeled NAD(+) and immunoblotting, we also demonstrate that both subunits of the XPC-RAD23B are poly(ADP-ribosyl)ated by PARP1. The efficiency of XPC-RAD23B PARylation depends on DNA structure and increases after UV irradiation of DNA. Therefore, our study clearly shows that XPC-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by PARP1, which can be regarded as a universal regulator of DNA repair processes.

摘要

聚（ADP-核糖）化是一种可逆的翻译后修饰，在许多细胞过程中发挥着重要作用，包括DNA修复的调控。通过合成聚（ADP-核糖）（PAR）介导的细胞DNA损伤反应主要由聚（ADP-核糖）聚合酶1（PARP1）介导。XPC-RAD23B复合物是参与初级DNA损伤识别的核苷酸切除修复的关键因素之一。通过使用几种生化方法，我们分析了PARP1和PAR合成对XPC-RAD23B与受损DNA相互作用的影响。游离的PAR以取决于聚（ADP-核糖）链长度的亲和力与XPC-RAD23B结合，并与DNA竞争蛋白质结合。使用（32）P标记的NAD（+）和免疫印迹，我们还证明XPC-RAD23B的两个亚基都被PARP1聚（ADP-核糖）化。XPC-RAD23B PARylation的效率取决于DNA结构，并在DNA紫外线照射后增加。因此，我们的研究清楚地表明，XPC-RAD23B是PARP1催化的聚（ADP-核糖）化的靶标，PARP1可被视为DNA修复过程的通用调节剂。