COVID-19 疫苗接种后葡萄膜黑色素瘤坏死。

Necrosis of uveal melanoma post-COVID-19 vaccination.

机构信息

International Eye Cataract Retina Centre, Mount Elizabeth Medical Centre and Farrer Park Medical Centre; Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore.

Department of Pathology, National University Hospital, National University of Singapore, Singapore.

出版信息

Indian J Ophthalmol. 2022 May;70(5):1837-1840. doi: 10.4103/ijo.IJO_3040_21.

DOI:10.4103/ijo.IJO_3040_21

PMID:35502089

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9333048/

Abstract

A 49-year-old Indian male presented with rapidly progressive vision loss 1 day after receiving the second dose of BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine (Pfizer-BioNTech, NY, USA). The eye had secondary angle closure glaucoma, bullous retinal detachment, and massive intraocular hemorrhage. Ultrasound showed an ill-defined subretinal mass with moderate internal reflectivity. Magnetic resonance imaging (MRI) confirmed an enhancing heterogeneous subretinal mass. Histopathology showed a necrotic melanocytic lesion arising from the posterior edge of the ciliary body and choroid. Necrotic uveal melanoma was confirmed after expert histopathology opinion. Uveal melanomas can rarely present with tumor necrosis following mRNA COVID-19 vaccination.

摘要

一位 49 岁的印度男性在接种第二剂 BNT162b2 mRNA 冠状病毒病 2019（COVID-19）疫苗（辉瑞-生物科技，纽约，美国）后 1 天出现视力迅速下降。眼睛患有继发性闭角型青光眼、疱状视网膜脱离和大量眼内出血。超声显示边界不清的视网膜下肿块，内部反射中度。磁共振成像（MRI）证实了增强的异质性视网膜下肿块。组织病理学显示睫状体和脉络膜后缘出现坏死性黑色素细胞病变。在专家组织病理学意见后证实为坏死性葡萄膜黑色素瘤。mRNA COVID-19 疫苗接种后，葡萄膜黑色素瘤很少会出现肿瘤坏死。