Jensen P K, Christiansen J S, Steven K, Parving H H
Kidney Int. 1987 Jan;31(1):47-51. doi: 10.1038/ki.1987.7.
Micropuncture studies were made on insulin-treated streptozotocin diabetic rats two weeks after the induction of diabetes and on age-matched control rats. Kidney size, GFR and single nephron GFR were higher in poorly controlled diabetic rats than in normal animals. Single nephron GFR rose as a result of an increase in the hydraulic pressure difference across the glomerular capillary wall caused mainly by a rise in the glomerular capillary pressure due to a diminished ratio of afferent to efferent arteriolar hydraulic resistances. Furthermore, the intratubular pressure was reduced as a result of a decrease in hydraulic resistance in the loop of Henle. Strict metabolic control prevented these changes. In conclusion, the increase in renal function in experimental diabetes is determined by the degree of metabolic control excluding a potential nephrotoxic effect of streptozotocin per se.
对糖尿病诱导两周后的胰岛素治疗链脲佐菌素糖尿病大鼠以及年龄匹配的对照大鼠进行了微穿刺研究。血糖控制不佳的糖尿病大鼠的肾脏大小、肾小球滤过率（GFR）和单肾单位GFR高于正常动物。单肾单位GFR升高是由于肾小球毛细血管壁两侧液压差增加所致，这主要是由于入球小动脉与出球小动脉液压阻力比值降低导致肾小球毛细血管压力升高。此外，由于亨利氏袢液压阻力降低，肾小管内压力降低。严格的代谢控制可防止这些变化。总之，实验性糖尿病中肾功能的增加取决于代谢控制程度，排除了链脲佐菌素本身潜在的肾毒性作用。
