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在体外放疗后前列腺癌骨转移分期中，锝-99m-前列腺特异性膜抗原单光子发射计算机断层扫描/计算机断层扫描（Tc-99m-PSMA-SPECT/CT）优于锝-99m-亚甲基二膦酸盐单光子发射计算机断层扫描/计算机断层扫描（Tc-99m-MDP-SPECT/CT） 。

Tc-99m-PSMA-SPECT/CT Is Superior to Tc-99m-MDP-SPECT/CT in the Staging of Prostatic Cancer with Osseous Metastases after External Beam Radiotherapy.

作者信息

Liepe Knut, Baehr Marcel

机构信息

Department of Nuclear Medicine, Klinikum Frankfurt (Oder), Frankfurt, Germany.

出版信息

World J Nucl Med. 2022 Mar 11;21(1):62-64. doi: 10.1055/s-0042-1744200. eCollection 2022 Mar.

DOI:10.1055/s-0042-1744200
PMID:35502276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9056129/
Abstract

In the reported patient with advanced prostate cancer, a bone scan showed a false positive finding in thoracic vertebrae bone metastasis after external beam radiotherapy 2 months ago. An additional Tc-99m-prostate-specific membrane antigen scan showed a negative finding, although nonirradiated iliac bone metastasis was concordantly positive in both scans. The decrease in prostate-specific antigen-level from 156.6 ng/mL to 2.3 ng/mL indicates a strong effect of treatment, hence supporting false positivity in bone scan by flare phenomenon.

摘要

在报道的这位晚期前列腺癌患者中，骨扫描显示在2个月前的外照射放疗后胸椎骨转移存在假阳性结果。额外的锝-99m前列腺特异性膜抗原扫描显示为阴性结果，尽管未受照射的髂骨转移在两次扫描中均一致为阳性。前列腺特异性抗原水平从156.6 ng/mL降至2.3 ng/mL表明治疗效果显著，因此支持骨扫描因闪烁现象出现假阳性。

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本文引用的文献

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Prognostic factors influencing overall survival in de novo oligometastatic prostate cancer patients.影响初发性寡转移前列腺癌患者总生存期的预后因素。
Prostate. 2020 Aug;80(11):850-858. doi: 10.1002/pros.24016. Epub 2020 Jun 5.
2
Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study.高风险前列腺癌患者在接受根治性手术或放疗前的前列腺特异性膜抗原 PET-CT（proPSMA）：一项前瞻性、随机、多中心研究。
Lancet. 2020 Apr 11;395(10231):1208-1216. doi: 10.1016/S0140-6736(20)30314-7. Epub 2020 Mar 22.
3
68Ga-PSMA PET/CT imaging in recurrent prostate cancer: Where are we now?
68Ga-PSMA PET/CT成像在复发性前列腺癌中的应用：我们目前的进展如何？
Cent European J Urol. 2017;70(1):37-43. doi: 10.5173/ceju.2017.947. Epub 2017 Jan 11.
4
Imaging metastatic bone disease from carcinoma of the prostate.前列腺癌转移性骨病的影像学表现
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