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New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.新型去铁胺化合物能有效螯合多余的铁，用于治疗铁过载疾病和预防铁死亡。
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Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders.重新利用吲哚菁绿可实现用于铁过载疾病的磁共振/光声成像信号放大和铁耗竭。
Sci Adv. 2021 Dec 17;7(51):eabl5862. doi: 10.1126/sciadv.abl5862.
2
Physiological variation of liver iron concentration may not be dominantly responsible for the liver T1rho variations associated with age and gender.肝脏铁浓度的生理变化可能并非与年龄和性别相关的肝脏T1rho变化的主要原因。
Quant Imaging Med Surg. 2021 Apr;11(4):1668-1673. doi: 10.21037/qims-20-1250.
3
Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-Invasive and Safe Strategy.多模态光声成像引导的角膜新生血管消退：一种非侵入性安全策略
Adv Sci (Weinh). 2020 May 29;7(14):2000346. doi: 10.1002/advs.202000346. eCollection 2020 Jul.
4
A superstable homogeneous lipiodol-ICG formulation for locoregional hepatocellular carcinoma treatment.一种超稳定的均相碘化油-ICG 制剂，用于局部肝癌治疗。
J Control Release. 2020 Jul 10;323:635-643. doi: 10.1016/j.jconrel.2020.04.021. Epub 2020 Apr 14.
5
A single-step multi-level supramolecular system for cancer sonotheranostics.用于癌症声治疗的单步多级超分子体系。
Nanoscale Horiz. 2019 Jan 1;4(1):190-195. doi: 10.1039/c8nh00276b. Epub 2018 Oct 15.
6
Activatable Fluorescence Probes for "Turn-On" and Ratiometric Biosensing and Bioimaging: From NIR-I to NIR-II.可激活荧光探针用于“开启”和比率型生物传感和生物成像：从近红外一区到近红外二区。
Bioconjug Chem. 2020 Feb 19;31(2):276-292. doi: 10.1021/acs.bioconjchem.9b00734. Epub 2020 Jan 28.
7
Evaluation of hepatic iron concentration heterogeneities using the MRI R2* mapping method.采用 MRI R2* 映射法评估肝铁浓度异质性。
Eur J Radiol. 2019 Jul;116:47-54. doi: 10.1016/j.ejrad.2018.02.011. Epub 2018 Feb 12.
8
Zinc(II)-Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy.锌（II）-二吡啶胺配位纳米诊疗剂：通过联合光/基因治疗实现协同纳米医学
Angew Chem Int Ed Engl. 2019 Jan 2;58(1):269-272. doi: 10.1002/anie.201812482. Epub 2018 Dec 5.
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Tumor Microenvironment-Responsive Ultrasmall Nanodrug Generators with Enhanced Tumor Delivery and Penetration.肿瘤微环境响应型超小纳米药物发生器，增强肿瘤递药和穿透能力。
J Am Chem Soc. 2018 Nov 7;140(44):14980-14989. doi: 10.1021/jacs.8b09396. Epub 2018 Oct 25.
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Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid-Based Assemblies.提升生物无机杂化脂质基组装体的药物潜力。
Adv Sci (Weinh). 2018 Jul 20;5(9):1800564. doi: 10.1002/advs.201800564. eCollection 2018 Sep.

Transforming a clinical fluorescent dye to sense and treat iron overload disorders: a new reverse translational approach in precision medicine.

作者信息

Wang Junqing, Liu Gang, Wáng Yì Xiáng J

机构信息

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.

出版信息

Quant Imaging Med Surg. 2022 May;12(5):3020-3023. doi: 10.21037/qims-2022-01.

DOI:10.21037/qims-2022-01
PMID:35502386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9014137/
Abstract
摘要