锁骨上与皮下质子密度脂肪分数之间的个体内差异与冷诱导产热有关。
Intraindividual difference between supraclavicular and subcutaneous proton density fat fraction is associated with cold-induced thermogenesis.
作者信息
Held Cora, Junker Daniela, Wu Mingming, Patzelt Lisa, Mengel Laura A, Holzapfel Christina, Diefenbach Maximilian N, Makowski Marcus R, Hauner Hans, Karampinos Dimitrios C
机构信息
Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
出版信息
Quant Imaging Med Surg. 2022 May;12(5):2877-2890. doi: 10.21037/qims-21-986.
BACKGROUND
Brown adipose tissue (BAT) activity is triggered by cold exposure resulting in an increased resting energy expenditure, called cold-induced non-shivering thermogenesis (CIT). Magnetic resonance (MR)-based proton density fat fraction (PDFF) of the supraclavicular fossa has been proposed as a surrogate marker of human BAT. The present study investigates supraclavicular PDFF in relation to CIT.
METHODS
For this prospective cross-sectional study 39 adults were recruited, from a cross-sectional study, exploring energy expenditure after cold exposure compared to thermoneutral conditions. Participants underwent additional MR examination of neck, pelvis, and abdomen. Supraclavicular and subcutaneous gluteal adipose tissue depots were segmented semi-automatically. Mean PDFF was assessed for each compartment and the delta PDFF was calculated as the difference of both. Correlation analysis of supraclavicular PDFF to CIT was performed for the whole cohort and subgroups, sorted by body mass index (BMI) and body fat percentage.
RESULTS
Median age of participants (61.5% female) was 27 years. BMI ranged from 19.0 to 38.5 kg/m, with body fat percentages from 4.6% to 45.3%. Median supraclavicular PDFF of 82.5% and median gluteal PDFF of 91.1%, were significantly different (P<0.0001). Median delta PDFF was 8.8% (3.9-21.9%). Mean CIT was 4.7%±9.0%. No statistically significant correlation of supraclavicular PDFF and CIT was found in the whole cohort and in most of the observed subgroups. Just the subgroup with normal body fat percentage revealed significant correlations between supraclavicular PDFF and CIT (rho =-0.59; P=0.003). Delta PDFF was significantly associated with CIT (rho =0.36; P=0.026).
CONCLUSIONS
PDFF is influenced by adiposity. Therefore, if supraclavicular PDFF is used as approach to indirectly assess BAT presence, body composition should be considered. Delta PDFF, as the difference between gluteal and supraclavicular PDFF, may be a marker of CIT.
背景
棕色脂肪组织（BAT）的活性由寒冷暴露触发，导致静息能量消耗增加，即冷诱导非寒战产热（CIT）。基于磁共振（MR）的锁骨上窝质子密度脂肪分数（PDFF）已被提议作为人类BAT的替代标志物。本研究调查锁骨上PDFF与CIT的关系。
方法
在一项探索寒冷暴露后与热中性条件下能量消耗对比的横断面研究中，招募了39名成年人进行本次前瞻性横断面研究。参与者接受了颈部、骨盆和腹部的额外MR检查。锁骨上和皮下臀脂肪组织库进行半自动分割。评估每个隔室的平均PDFF，并计算δPDFF作为两者的差值。对整个队列和按体重指数（BMI）和体脂百分比分类的亚组进行锁骨上PDFF与CIT的相关性分析。
结果
参与者的中位年龄为27岁（女性占61.5%）。BMI范围为19.0至38.5kg/m²，体脂百分比为4.6%至45.3%。锁骨上PDFF中位数为82.5%，臀PDFF中位数为91.1%，差异有统计学意义（P<0.0001）。δPDFF中位数为8.8%（3.9 - 21.9%）。平均CIT为4.7%±9.0%。在整个队列和大多数观察到的亚组中，未发现锁骨上PDFF与CIT有统计学意义的相关性。只有体脂百分比正常的亚组显示锁骨上PDFF与CIT之间存在显著相关性（rho = -0.59；P = 0.003）。δPDFF与CIT显著相关（rho = 0.36；P = 0.026）。
结论
PDFF受肥胖影响。因此，如果将锁骨上PDFF用作间接评估BAT存在的方法，则应考虑身体成分。作为臀和锁骨上PDFF差值的δPDFF可能是CIT的标志物。
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