Urological and sexological clinical outpatient clinic, Department of Urology, University Hospital Bratislava, Ružinovská 6, 82601 Bratislava, Slovakia.
Physiol Res. 2021 Nov 30;70(Suppl 1):S99-S107.
High incidence of infertility along with low vitamin D levels was detected in otherwise healthy young men. The aim is to observe the effect of vitamin D supplementation on semen parameters as assessed by semen analysis in infertile men. In total, 45 men (mean age 36.6 years) in consecutive order were included, of whom 34 finished the study. Subjects were supplemented by vitamin D (cholecalciferol) 2500 IU/day. Vitamin D levels were assessed by HPLC. Semen analysis was performed strictly following 2010 WHO guidelines. Study periods were baseline and month 6. During follow-up, 20 %, 7.4 %, 22 % and 0.7 % increase in serum vitamin D levels, progressive sperm motility, sperm concentration and sperm morphology, respectively, were observed (all p<0.05). At follow-up end, 9 patients (26 %) reached normal sperm parameters of whom 2 fertilized their partner. There was no correlation between vitamin D and semen parameters observed. This study proves that vitamin D supplementation is possibly a modulator of sperm parameters in vitamin D deficient, otherwise healthy men. Although a direct relationship between vitamin D and sperm parameters was not observed obtaining adequate vitamin D levels could likely play a role in the male factor of infertility.
在健康的年轻男性中，不育症的发病率较高，同时维生素 D 水平较低。目的是观察维生素 D 补充对不育男性精液参数的影响，通过精液分析进行评估。总共连续纳入了 45 名男性（平均年龄 36.6 岁），其中 34 名完成了研究。受试者每天补充维生素 D（胆钙化醇）2500IU。通过 HPLC 评估维生素 D 水平。精液分析严格按照 2010 年世卫组织指南进行。研究期间为基线和第 6 个月。在随访期间，血清维生素 D 水平分别增加了 20%、7.4%、22%和 0.7%，精子活力、精子浓度和精子形态也分别逐渐增加（均 p<0.05）。随访结束时，9 名患者（26%）达到正常精子参数，其中 2 名使伴侣受精。维生素 D 与精液参数之间没有观察到相关性。这项研究证明，维生素 D 补充可能是维生素 D 缺乏的健康男性精子参数的调节剂。尽管未观察到维生素 D 和精子参数之间的直接关系，但获得足够的维生素 D 水平可能在不育症的男性因素中发挥作用。
