Pharmacy School, Universidade Federal do Rio Grande do Sul.
Post-Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul.
Int Clin Psychopharmacol. 2022 Sep 1;37(5):229-230. doi: 10.1097/YIC.0000000000000411. Epub 2022 May 2.
Ketamine can be used for depression and suicidal ideation due to its effectiveness and low complication rates; moreover, allergic reactions are rare. Immediately after subcutaneous (SC) ketamine administration, a 22-year-old man rapidly developed hives on the trunk and face without oxygen desaturation. Symptoms disappeared after treatment with prednisolone. This case presents an allergic reaction to ketamine compatible with mast cell activation and release of preformed mediators, without being able to prove whether the event was mediated by immunoglobulin E. This is the only case reported to date of an allergic reaction to SC ketamine for psychiatric treatment.
氯胺酮可有效且并发症发生率低，因此可用于治疗抑郁症和自杀意念；此外，氯胺酮极少引起过敏反应。一名 22 岁男性在接受皮下注射氯胺酮后，迅速出现躯干和面部风团，无低氧血症。给予泼尼松龙治疗后，症状消失。本例为氯胺酮过敏反应，符合肥大细胞活化和预先形成的介质释放，无法确定该事件是否由免疫球蛋白 E 介导。这是迄今为止唯一报道的用于精神科治疗的皮下注射氯胺酮过敏反应的病例。
