Liu Xin-Bei, Liu Wen-Jing
School of Medicine, Yunnan University, Kunming 650091, China.
Sheng Li Xue Bao. 2022 Apr 25;74(2):320-332.
Renal ischemia-reperfusion injury (IRI) is histologically characterized by tubular cell death. Diverse pathways of regulated cell death (RCD) have been reported to contribute to renal IRI in recent studies. In this review, we discuss the signaling pathways, regulators and crosstalk of RCD, including necroptosis, ferroptosis and pyroptosis, and their role in renal IRI in order to pave the way for new therapeutic opportunities.
肾缺血再灌注损伤（IRI）在组织学上的特征是肾小管细胞死亡。近年来的研究报道，多种程序性细胞死亡（RCD）途径参与了肾IRI的发生。在这篇综述中，我们讨论了RCD的信号通路、调节因子和相互作用，包括坏死性凋亡、铁死亡和焦亡，以及它们在肾IRI中的作用，以便为新的治疗机会铺平道路。
