King Abdullah International Medical Research Center (KAIMRC)-Eastern Region, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard-Health Affairs (MNG-HA), Al Ahsa, Saudi Arabia.
Adv Exp Med Biol. 2022;1372:57-65. doi: 10.1007/978-981-19-0394-6_5.
Sphingolipids are biomolecules with diverse physiological functions in signaling as well as plasma membrane structure. They are associated with either cellular membranes or plasma lipoproteins and any changes in their levels may contribute to certain metabolic diseases. Sphingolipids are evenly distributed in lipoproteins and may be used as prognostic and diagnostic markers. Mechanisms involved in the transport of sphingolipids have been recently explored and here we discuss the most recent advances in the molecular mechanisms of sphingolipids transport by lipoproteins. It has been shown that microsomal triglyceride transfer protein (MTP) and ATP-binding cassette transporter family A protein 1 (ABCA1) play an important role in plasma sphingolipid homeostasis. However, the exact mechanisms are not well known. Though much research has already been done to emphasize the impact of sphingolipids changes in many pathological disorders, understanding mechanisms by which circulating lipoproteins assist in transporting sphingolipids may provide novel information that may help in devising strategies to therapeutically target these pathways to treat various metabolic disorders.
鞘脂类是具有多种生理功能的生物分子，在信号转导以及质膜结构中发挥作用。它们与细胞膜或血浆脂蛋白有关，其水平的任何变化都可能导致某些代谢疾病。鞘脂类均匀分布在脂蛋白中，可用作预后和诊断标志物。最近已经探索了鞘脂类运输的机制，在这里我们讨论了脂蛋白转运鞘脂类的分子机制的最新进展。已经表明，微粒体甘油三酯转移蛋白（MTP）和 ATP 结合盒转运蛋白家族 A 成员 1（ABCA1）在血浆鞘脂类稳态中发挥重要作用。然而，确切的机制尚不清楚。尽管已经进行了大量研究来强调鞘脂类变化在许多病理紊乱中的影响，但了解循环脂蛋白在转运鞘脂类方面的作用机制可能提供新的信息，这可能有助于制定策略来靶向这些途径治疗各种代谢紊乱。
