Department of thoracic surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
State Key Laboratory of Electroanalytical Chemistry, Research Center of Biomembranomics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
Life Sci. 2022 Jul 15;301:120600. doi: 10.1016/j.lfs.2022.120600. Epub 2022 May 2.
CUB domain-containing protein 1 (CDCP1), as an emerging transmembrane protein, is overexpressed in a variety of malignant tumors including respiratory tumors, digestive system cancers, hematological malignancies and urogenital cancers. Several cancer-related proteins have been reported to interact with CDCP1. It acts as a crucial hub in multiple classical signaling pathways of tumorigenesis and progression. Its overexpression and activation are also associated with prognosis and drug resistance. Due to its important roles in malignant tumors, CDCP1 is expected to be a promising therapeutic target for treatment and a new biomarker for diagnosis. In this article, we review the roles of CDCP1 in diagnosis and management of malignant tumors, and also its regulation in several essential tumor-related pathways.
CUB 结构域包含蛋白 1（CDCP1）作为一种新兴的跨膜蛋白，在多种恶性肿瘤中过表达，包括呼吸系统肿瘤、消化系统癌症、血液系统恶性肿瘤和泌尿生殖系统癌症。已经报道了几种与 CDCP1 相互作用的癌症相关蛋白。它作为肿瘤发生和进展的多个经典信号通路中的关键枢纽发挥作用。其过表达和激活也与预后和耐药性相关。由于其在恶性肿瘤中的重要作用，CDCP1 有望成为治疗的有前途的治疗靶点和新的诊断生物标志物。在本文中，我们综述了 CDCP1 在恶性肿瘤的诊断和治疗中的作用，以及其在几个重要的肿瘤相关通路中的调控作用。
