Department of Life Science, Ewha Womans University, Seoul 03760, South Korea; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, South Korea.
Department of Life Science, Ewha Womans University, Seoul 03760, South Korea; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, South Korea.
Joint Bone Spine. 2022 Oct;89(5):105400. doi: 10.1016/j.jbspin.2022.105400. Epub 2022 Apr 30.
Osteoclast-associated receptor (OSCAR) is a member of the leukocyte receptor complex (LRC)-encoded protein family, which is characterized by the presence of immunoglobulin (Ig)-like domains. OSCAR recognizes collagen and was first identified as a co-stimulatory receptor that is needed for complete osteoclast differentiation. However, it is now clear that OSCAR is also expressed by multiple immune cells that participate in many innate and adaptive immune cell activities. We also showed recently that chondrocytes express OSCAR. Our and other studies suggest that OSCAR participates in the pathogenesis of two common joint diseases, namely, rheumatoid arthritis (RA) and osteoarthritis (OA). Specifically, OSCAR promotes osteoclast formation and therefore bone erosion in RA while in OA, it triggers chondrocyte death, thereby inducing cartilage fragility. Significantly, blocking the interaction of OSCAR with its collagen ligand can markedly reduce these activities in vitro and in vivo. Thus, this novel approach may have therapeutic potential for joint diseases.
破骨细胞相关受体 (OSCAR) 是白细胞受体复合物 (LRC) 编码蛋白家族的成员，其特征是存在免疫球蛋白 (Ig) 样结构域。OSCAR 识别胶原，最初被鉴定为一种共刺激受体，对于完全破骨细胞分化是必需的。然而，现在很清楚，OSCAR 也表达于参与许多先天和适应性免疫细胞活动的多种免疫细胞。我们最近还表明软骨细胞表达 OSCAR。我们和其他研究表明，OSCAR 参与两种常见关节疾病的发病机制，即类风湿关节炎 (RA) 和骨关节炎 (OA)。具体而言，OSCAR 促进 RA 中的破骨细胞形成和因此的骨质侵蚀，而在 OA 中，它触发软骨细胞死亡，从而诱导软骨脆弱。重要的是，阻断 OSCAR 与其胶原配体的相互作用可以显著减少体外和体内的这些活性。因此，这种新方法可能具有治疗关节疾病的潜力。
