细胞外囊泡诱导的环腺苷酸信号通路。
Extracellular vesicle-induced cyclic AMP signaling.
机构信息
Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, United States of America; Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, Alabama.
Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, United States of America; Department of Chemical and Biomolecular Engineering, College of Engineering, University of South Alabama, Mobile, AL, United States of America; Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, Alabama.
出版信息
Cell Signal. 2022 Jul;95:110348. doi: 10.1016/j.cellsig.2022.110348. Epub 2022 Apr 30.
Second messenger signaling is required for cellular processes. We previously reported that extracellular vesicles (EVs) from stimulated cultured endothelial cells contain the biochemical second messenger, cAMP. In the current study, we sought to determine whether cAMP-enriched EVs induce second messenger signaling pathways in naïve recipient cells. Our results indicate that cAMP-enriched EVs increase cAMP content sufficient to stimulate PKA activity. The implications of our work are that EVs represent a novel intercellular mechanism for second messenger, specifically cAMP, signaling.
第二信使信号转导对于细胞过程至关重要。我们之前曾报道，经刺激的培养内皮细胞来源的细胞外囊泡（EVs）中含有生化第二信使 cAMP。在本研究中，我们旨在确定富含 cAMP 的 EV 是否可在初始受体细胞中诱导第二信使信号通路。我们的研究结果表明，富含 cAMP 的 EV 可增加足以刺激 PKA 活性的 cAMP 含量。我们的研究工作表明，EV 代表了一种新的细胞间第二信使（特别是 cAMP）信号转导机制。
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