Department of Orthopedics, Orthopedic Research Institute, and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Division of Nephrology, Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Med-X Center for Informatics, Sichuan University, Chengdu, China.
Osteoarthritis Cartilage. 2022 Aug;30(8):1079-1090. doi: 10.1016/j.joca.2022.04.004. Epub 2022 Apr 30.
The effect of physical activity on hip/knee osteoarthritis (OA) and how it varies by genetic susceptibility to OA remains inconclusive.
In a cohort study of UK Biobank, 436,166 OA-free participants were recruited in 2006-2010 and followed for knee/hip OA until the end of 2020. 28 physical activity-related items were collected at baseline. Cox regression was used to estimate associations between physical activity behaviors, as well as major activity patterns (i.e., significant principal components[PCs] identified by principal component analysis), and risk of OA, adjusting for multiple confounders. We further stratified the analyses by polygenic risk score (PRS) for OA to examine the impact of genetic susceptibility to OA on the studied association.
During a mean follow-up of 11.15 years, 13,227 hip and 21,119 knee OA cases were identified. 19, out of 28, studied items showed associations with increased OA risk. Compared with low adherence group(<1 tertile of PC score for each pattern), individuals with high adherence to five identified patterns were associated with increased risk of OA. The moderate adherence to "strenuous sports"(HR = 0.93, 95%CI: 0.89-0.97) and "walking for pleasure"(HR = 0.93, 95%CI: 0.89-0.98) patterns was associated with reduced OA. Similar risk patterns were obtained in the stratified analysis by PRS levels for OA.
High intensity of most activity patterns were associated with increased OA. However, a protective effect was suggested for moderate adherence to patterns of "strenuous sports" and "walking for pleasure" that consistent across different genetic susceptibilities, underscoring the potential benefits of moderate-intensity physical activity on OA.
体力活动对髋/膝关节骨关节炎（OA）的影响及其与 OA 遗传易感性的差异仍不确定。
在英国生物银行的一项队列研究中，于 2006-2010 年招募了 436166 名无 OA 的参与者，并在 2020 年底前对膝关节/髋关节 OA 进行随访。在基线时收集了 28 项与体力活动相关的项目。使用 Cox 回归估计体力活动行为以及主要活动模式（即通过主成分分析确定的重要主成分）与 OA 风险之间的关联，同时调整了多种混杂因素。我们进一步按 OA 的多基因风险评分（PRS）进行分层分析，以检查 OA 的遗传易感性对研究关联的影响。
在平均 11.15 年的随访期间，共确定了 13227 例髋部和 21119 例膝关节 OA 病例。在 28 个研究项目中，有 19 个与 OA 风险增加相关。与低依从性组（每种模式 PC 评分的<1 三分位）相比，五个确定模式的高依从性与 OA 风险增加相关。中度坚持“剧烈运动”（HR=0.93，95%CI：0.89-0.97）和“散步为乐”（HR=0.93，95%CI：0.89-0.98）模式与 OA 减少相关。在按 OA 的 PRS 水平进行分层分析中，也获得了相似的风险模式。
大多数活动模式的高强度与 OA 增加相关。然而，对于“剧烈运动”和“散步为乐”模式的中度坚持，提示存在保护作用，且在不同遗传易感性中一致，强调了中等强度体力活动对 OA 的潜在益处。
