非囊性纤维化支气管扩张症患者的年 FEV 损失及影响因素。

Annual FEV Loss in Patients with Noncystic Fibrosis Bronchiectasis and Affecting Factors.

机构信息

From the Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa, Istanbul, Turkey.

出版信息

South Med J. 2022 May;115(5):328-332. doi: 10.14423/SMJ.0000000000001394.

DOI:10.14423/SMJ.0000000000001394

PMID:35504615

Abstract

OBJECTIVES

Bronchiectasis is a chronic respiratory disease characterized by sputum production, cough, and several bronchial infections. Lung function is an important parameter to evaluate and study in patients with bronchiectasis. This study aimed to evaluate the annual changes in forced expiratory volume in one second (FEV) and related factors in patients with with noncystic fibrosis bronchiectasis.

METHODS

A total of 529 patients who were diagnosed as having bronchiectasis using computed tomography and followed at the bronchiectasis unit of the Cerrahpasa Medical Faculty at Istanbul University between 1996 and 2018 were included in this retrospective study. A total of 153 patients were included in the study.

RESULTS

The mean age of the patients was 58.6 ± 16.8 years and 61% (n = 93) were female. The annual change of FEV and forced vital capacity was -39 ± 82 (minimum: -585, maximum: 355, median: -26) mL and - 44 ± 91 (minimum: -517, maximum: 303, median: -31) mL, respectively. There was no correlation in FEV decline between those with and without colonization ( = 0.65). No correlation was found between the etiologic factors and the decline of FEV. A correlation existed only between the first FEV and the decline of FEV (for the first FEV%, 0.038 [R = -0.17]; for the first FEV [mL] 0.026 [R = -0.18]).

CONCLUSIONS

An annual mean FEV loss of 39 mL was found in adult patients with noncystic fibrosis bronchiectasis. The annual mean FEV decline was found to be associated with the baseline FEV value. Physicians should exercise caution in this regard in patients with bronchiectasis with low FEV values.

摘要

目的

支气管扩张症是一种以咳痰、咳嗽和多次支气管感染为特征的慢性呼吸道疾病。肺功能是评估和研究支气管扩张症患者的重要参数。本研究旨在评估非囊性纤维化支气管扩张症患者的用力呼气量（FEV）的年度变化及其相关因素。

方法

本回顾性研究纳入了 1996 年至 2018 年间在伊斯坦布尔大学 Cerrahpasa 医学系支气管扩张科通过计算机断层扫描诊断为支气管扩张症并接受随访的 529 例患者，其中共有 153 例患者被纳入研究。

结果

患者的平均年龄为 58.6±16.8 岁，61%（n=93）为女性。FEV 和用力肺活量的年变化分别为-39±82（最小：-585，最大：355，中位数：-26）mL 和-44±91（最小：-517，最大：303，中位数：-31）mL。在有无定植的患者之间，FEV 下降无相关性（ = 0.65）。病因因素与 FEV 下降之间未发现相关性。仅在 FEV 与 FEV 下降之间存在相关性（对于 FEV%，0.038[R=-0.17]；对于 FEV[mL]，0.026[R=-0.18]）。