DuBose Stephanie N, Kanapka Lauren G, Bradfield Brenda, Sooy Morgan, Beck Roy W, Steck Andrea K
Jaeb Center for Health Research, Tampa, Florida 33647, USA.
Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
J Endocr Soc. 2022 Apr 9;6(6):bvac060. doi: 10.1210/jendso/bvac060. eCollection 2022 Jun 1.
Continuous glucose monitoring (CGM) is increasingly being used both for day-to-day management in patients with diabetes and in clinical research. While data on glycemic profiles of healthy, nondiabetic individuals exist, data on nondiabetic very young children are lacking.
This work aimed to establish reference sensor glucose ranges in healthy, nondiabetic young children, using a current-generation CGM sensor.
This prospective observational study took place in an institutional practice with healthy, nondiabetic children aged 1 to 6 years with normal body mass index. A blinded Dexcom G6 Pro CGM was worn for approximately 10 days by each participant. Main outcome measures included CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability.
Thirty-nine participants were included in the analyses. Mean average glucose was 103 mg/dL (5.7 mmol/L). Median percentage time between 70 and 140 mg/dL (3.9-7.8 mmol/L) was 96% (interquartile range, 92%-97%), mean within-individual coefficient of variation was 17 ± 3%, median time spent with glucose levels greater than 140 mg/dL was 3.4% (49 min/day), and median time less than 70 mg/dL (3.9 mmol/L) was 0.4% (6 min/day).
Collecting normative sensor glucose data and describing glycemic measures for young children fill an important informational gap and will be useful as a benchmark for future clinical studies.
连续血糖监测（CGM）越来越多地用于糖尿病患者的日常管理和临床研究。虽然有关于健康非糖尿病个体血糖谱的数据，但缺乏非糖尿病幼儿的数据。
本研究旨在使用新一代CGM传感器确定健康非糖尿病幼儿的参考传感器葡萄糖范围。
这项前瞻性观察性研究在一家机构诊所进行，研究对象为体重指数正常的1至6岁健康非糖尿病儿童。每位参与者佩戴盲法德康G6 Pro CGM约10天。主要观察指标包括平均血糖、高血糖、低血糖和血糖变异性的CGM指标。
39名参与者纳入分析。平均血糖为103mg/dL（5.7mmol/L）。血糖在70至140mg/dL（3.9 - 7.8mmol/L）之间的中位时间百分比为96%（四分位间距，92% - 97%），个体内变异系数平均值为17±3%，血糖水平高于140mg/dL的中位时间为3.4%（49分钟/天），低于70mg/dL（3.9mmol/L）的中位时间为0.4%（6分钟/天）。
收集幼儿的标准传感器葡萄糖数据并描述血糖测量结果填补了重要的信息空白，将作为未来临床研究的基准。
