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从 和 和 中提取厚朴酚并研究其抗真菌活性。

Extraction of honokiol from and and investigation of its antifungal activity.

机构信息

Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao, China.

Zunyi Branch, Guizhou Tobacco Company, Zunyi, China.

出版信息

Nat Prod Res. 2023 Feb;37(4):651-656. doi: 10.1080/14786419.2022.2071887. Epub 2022 May 4.

DOI:10.1080/14786419.2022.2071887
PMID:35506313
Abstract

Extracts from plants used in Chinese medicine can be good sources of fungicides for agricultural applications. In this study, we separated and identified antifungal compounds from four traditional Chinese medicine extracts and evaluated their antifungal activities and . , honokiol extracted from showed broad-spectrum antimicrobial and mycelial inhibitory activity with EC in the range 3.56 - 33.85 μg/mL against eight plant pathogens. q-PCR indicated that honokiol might induce cell cancerisation and inhibit cellular respiration, which provided significant insights into honokiol function in tobacco resistance to molecular mechanisms of the phytopathogenic fungus . , honokiol significantly decreased the rate of fungal infection in eggplants, potatoes, grapes, cherry tomatoes, and cucumbers, and enhanced disease resistance in tobacco. Overall, our results indicate that honokiol has the potential to control a variety of fungal and oomycete diseases, and could be a source of honokiol.

摘要

从中药植物中提取的物质可以成为农业用杀菌剂的良好来源。在这项研究中,我们从四种中药提取物中分离并鉴定了抗真菌化合物,并评估了它们的抗真菌活性。从厚朴中提取的厚朴酚对 8 种植物病原菌具有广谱的抗菌和菌丝抑制活性,EC 在 3.56-33.85μg/mL 范围内。q-PCR 表明,厚朴酚可能诱导细胞癌变并抑制细胞呼吸,这为厚朴酚在烟草对植物病原菌的分子机制中的作用提供了重要的见解。综上所述,我们的结果表明,厚朴酚有可能控制多种真菌和卵菌病害,并且厚朴可能是厚朴酚的来源。

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