Breddin H K, Weichert W
Pathol Biol (Paris). 1987 Feb;35(2 Pt 2):223-5.
Molsidomine and SIN-1 were tested in a thrombosis model in which thrombi are produced in small mesenteric vessels. An interference contrast system based on a Leitz Orthoplan microscope was used to visualize thrombus formation. Vascular lesions were produced with a Coherent CR-Z supergraphite ion laser (Argon laser) in vessel of 20-30 micron diameter. Molsidomine and SIN-1 i.v. at doses of 0.1 and 0.5 mg/kg had a marked and significant antithrombotic effect in arterioles and in venules. Molsidomine at doses of 0.1 and 0.5 mg/kg had no antithrombotic effect 90 min following intravenous injection.
在一个血栓形成模型中对吗多明和SIN-1进行了测试，该模型中在小肠系膜小血管中形成血栓。基于徕卡Orthoplan显微镜的干涉对比系统用于观察血栓形成。使用相干CR-Z超石墨离子激光（氩激光）在直径为20 - 30微米的血管中造成血管损伤。静脉注射剂量为0.1和0.5毫克/千克的吗多明和SIN-1在小动脉和小静脉中具有显著的抗血栓作用。静脉注射后90分钟，剂量为0.1和0.5毫克/千克的吗多明没有抗血栓作用。
