[Inhibition of the formation of platelet thrombus by molsidomine and SIN-1 in the mesenteric vessels rats].

Molsidomine and SIN-1 were tested in a thrombosis model in which thrombi are produced in small mesenteric vessels. An interference contrast system based on a Leitz Orthoplan microscope was used to visualize thrombus formation. Vascular lesions were produced with a Coherent CR-Z supergraphite ion laser (Argon laser) in vessel of 20-30 micron diameter. Molsidomine and SIN-1 i.v. at doses of 0.1 and 0.5 mg/kg had a marked and significant antithrombotic effect in arterioles and in venules. Molsidomine at doses of 0.1 and 0.5 mg/kg had no antithrombotic effect 90 min following intravenous injection.