Grodzinska L, Basista M, Koenig E
Pathol Biol (Paris). 1987 Feb;35(2 Pt 2):233-4.
Molsidomine and its active metabolite SIN-1 were examined in humans and animals for their fibrinolytic and antithrombotic activity. In humans six and eight hours after ingestion of molsidomine retard (8 mg) a marked shortening of euglobulin clot lysis time was observed. Neither molsidomine nor SIN-1 activated fibrinolysis in vitro. In rabbits SIN-1 decreased the size of arterial and venous thrombus. Similar results were obtained with urokinase.
在人和动物身上研究了吗多明及其活性代谢产物SIN - 1的纤溶和抗血栓活性。在人类中，口服缓释吗多明（8毫克）6小时和8小时后，观察到优球蛋白凝块溶解时间显著缩短。吗多明和SIN - 1在体外均未激活纤溶作用。在兔子身上，SIN - 1减小了动脉和静脉血栓的大小。用尿激酶也得到了类似的结果。
