Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Department of Neuroscience, Psychology and Behaviour, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
Curr Top Behav Neurosci. 2022;57:395-414. doi: 10.1007/7854_2022_343.
The use of multiple species to model complex human psychiatric disorders, such as ADHD, can give important insights into conserved evolutionary patterns underlying multidomain behaviors (e.g., locomotion, attention, and impulsivity). Here we discuss the advantages and challenges in modelling ADHD-like phenotypes in zebrafish (Danio rerio), a vertebrate species that has been widely used in neuroscience and behavior research. Moreover, multiple behavioral tasks can be used to model the core symptoms of ADHD and its comorbidities. We present a critical review of current ADHD studies in zebrafish, and how this species might be used to accelerate the discovery of new drug treatments for this disorder.
使用多种物种来模拟复杂的人类精神疾病，如注意力缺陷多动障碍（ADHD），可以深入了解多维行为（如运动、注意力和冲动）背后保守的进化模式。在这里，我们讨论了在斑马鱼（Danio rerio）中模拟类似 ADHD 表型的优势和挑战，斑马鱼是一种在神经科学和行为研究中广泛使用的脊椎动物物种。此外，还可以使用多种行为任务来模拟 ADHD 的核心症状及其共病。我们对目前在斑马鱼中进行的 ADHD 研究进行了批判性回顾，并探讨了如何利用这种物种加速发现治疗这种疾病的新药物。
