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When the BBB goes MIA.

作者信息

Pearson Caroline A, Iadecola Costantino

机构信息

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021.

出版信息

Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2204159119. doi: 10.1073/pnas.2204159119. Epub 2022 May 4.

DOI:10.1073/pnas.2204159119
PMID:35507877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9171801/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5fe/9171801/7c98e9f8f9b1/pnas.2204159119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5fe/9171801/7c98e9f8f9b1/pnas.2204159119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5fe/9171801/7c98e9f8f9b1/pnas.2204159119fig01.jpg

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本文引用的文献

1
Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation.环氧化酶激活导致产前血脑屏障形成障碍,进而导致终身脑炎症。
Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2113310119. doi: 10.1073/pnas.2113310119. Epub 2022 Apr 4.
2
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.产前白细胞介素 6 水平升高会增加谷氨酸能突触密度,并破坏后代海马体的连接。
Immunity. 2021 Nov 9;54(11):2611-2631.e8. doi: 10.1016/j.immuni.2021.10.006.
3
Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.
小胶质细胞和与中枢神经系统相关的巨噬细胞——从起源到疾病调节。
Annu Rev Immunol. 2021 Apr 26;39:251-277. doi: 10.1146/annurev-immunol-093019-110159. Epub 2021 Feb 8.
4
Maternal immune activation induces sustained changes in fetal microglia motility.母体免疫激活诱导胎儿小胶质细胞运动持续改变。
Sci Rep. 2020 Dec 7;10(1):21378. doi: 10.1038/s41598-020-78294-2.
5
Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders.环氧化酶-2(COX-2)抑制剂在神经精神疾病炎症中的神经生物学及治疗潜力
Front Psychiatry. 2019 Sep 4;10:605. doi: 10.3389/fpsyt.2019.00605. eCollection 2019.
6
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat Model.激活的小胶质细胞破坏血脑屏障并在大鼠模型中诱导趋化因子和细胞因子
Front Cell Neurosci. 2018 Dec 13;12:494. doi: 10.3389/fncel.2018.00494. eCollection 2018.
7
Maternal immune activation, central nervous system development and behavioral phenotypes.母体免疫激活、中枢神经系统发育和行为表型。
Birth Defects Res. 2018 Dec 1;110(20):1539-1550. doi: 10.1002/bdr2.1416. Epub 2018 Nov 14.
8
Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells.白细胞介素-1β通过 Wnt5a/RhoA/JNK 通路促进皮质神经前体细胞的神经元分化。
Mol Brain. 2018 Jul 4;11(1):39. doi: 10.1186/s13041-018-0383-6.
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Maternal immune activation in neurodevelopmental disorders.神经发育障碍中的母体免疫激活。
Dev Dyn. 2018 Apr;247(4):588-619. doi: 10.1002/dvdy.24612. Epub 2017 Dec 23.
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The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.神经血管单元的成熟:健康与疾病中神经血管耦合的历程
Neuron. 2017 Sep 27;96(1):17-42. doi: 10.1016/j.neuron.2017.07.030.