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Y-radioembolisation in hepatocellular carcinoma induces immune responses calling for early treatment with multiple checkpoint blockers.

作者信息

Rivoltini Licia, Bhoori Sherrie, Camisaschi Chiara, Bergamaschi Laura, Lalli Luca, Frati Paola, Citterio Davide, Castelli Chiara, Mazzaferro Vincenzo

机构信息

Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy

HPB Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

出版信息

Gut. 2023 Feb;72(2):406-407. doi: 10.1136/gutjnl-2021-326869. Epub 2022 May 4.

DOI:10.1136/gutjnl-2021-326869
PMID:35508369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9872224/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/783c/9872224/d6a5f199d725/gutjnl-2021-326869f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/783c/9872224/d6a5f199d725/gutjnl-2021-326869f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/783c/9872224/d6a5f199d725/gutjnl-2021-326869f01.jpg

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Immunity. 2021 Aug 10;54(8):1825-1840.e7. doi: 10.1016/j.immuni.2021.06.013. Epub 2021 Jul 15.
2
Systemic immunity in cancer.癌症的系统性免疫。
Nat Rev Cancer. 2021 Jun;21(6):345-359. doi: 10.1038/s41568-021-00347-z. Epub 2021 Apr 9.
3
CD8 T Cell Responses during HCV Infection and HCC.丙型肝炎病毒感染和肝癌过程中的CD8 T细胞反应
钇-90 诱导具有新抗原克隆型扩增的效应记忆反应:免疫治疗的意义。
Cancer Res Commun. 2024 Aug 1;4(8):2163-2173. doi: 10.1158/2767-9764.CRC-24-0228.
4
The association between tumour heterogeneity and immune evasion mechanisms in hepatocellular carcinoma and its clinical implications.肝细胞癌中肿瘤异质性与免疫逃逸机制的关联及其临床意义。
Br J Cancer. 2024 Aug;131(3):420-429. doi: 10.1038/s41416-024-02684-w. Epub 2024 May 17.
5
Real-World Data on the Diagnosis, Treatment, and Management of Hepatocellular Carcinoma in the Asia-Pacific: The INSIGHT Study.亚太地区肝细胞癌诊断、治疗与管理的真实世界数据:洞察研究
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