Department of Internal Medicine, Stavanger University Hospital, Pb. 8100, 4068, Stavanger, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
Sci Rep. 2022 May 4;12(1):7281. doi: 10.1038/s41598-022-11802-8.
Fatigue is increasingly recognized as a major complaint in patients with chronic inflammatory and autoimmune diseases. Although fatigue is assumed to represent a significant problem in celiac disease, existing knowledge is scarce, and opinions are conflicting. This study aimed to investigate the prevalence and severity of fatigue in patients with newly diagnosed celiac disease and compare it with healthy control subjects. Ninety patients with newly diagnosed celiac disease were compared with 90 age- and sex-matched healthy subjects. The primary endpoints were fatigue severity as measured by: the fatigue Visual Analog Scale (fVAS), the Fatigue Severity Scale (FSS), and the inverted Vitality subscale of the MOS36 (SF-36vs). Higher scores indicate more severe fatigue. Clinically relevant fatigue was determined using predefined cut-off values. Secondary endpoints were the associations between fatigue, and sex, age, depression, pain, and selected biochemical variables. The median (IQR) fVAS-scores were 43.0 (18.0-64.5) in patients, and 9.0 (2.0-16.0) in the control group (p < 0.001); and the FSS scores 3.8 (2.0-4.8) in patients, and 1.4 (1.0-1.9) in control subjects (p < 0.001). Inverted SF-36vs scores had a mean (SD) value of 58.8 (23.6) in patients, and 29.7 (14.3) in healthy subjects (p < 0.001). The presence of clinically relevant fatigue ranged from 41 to 50% in patients. Increased fatigue severity was associated with female sex, younger age, and elevated pain and depression scores, but not with levels of selected biochemical variables, including hemoglobin. Fatigue is a severe and frequent phenomenon in patients with untreated celiac disease.
疲劳是慢性炎症性和自身免疫性疾病患者越来越常见的主诉。虽然人们认为乳糜泻患者的疲劳问题很严重，但目前相关知识匮乏，且观点存在分歧。本研究旨在调查新诊断为乳糜泻患者的疲劳发生率和严重程度，并与健康对照组进行比较。将 90 例新诊断为乳糜泻的患者与 90 名年龄和性别匹配的健康受试者进行比较。主要终点是疲劳严重程度的测量：疲劳视觉模拟量表（fVAS）、疲劳严重程度量表（FSS）和 MOS36 中的活力逆量表（SF-36vs）。得分越高表示疲劳越严重。使用预设的临界值确定有临床意义的疲劳。次要终点是疲劳与性别、年龄、抑郁、疼痛和选定生化变量之间的相关性。患者的 fVAS 评分中位数（IQR）为 43.0（18.0-64.5），对照组为 9.0（2.0-16.0）（p<0.001）；FSS 评分患者为 3.8（2.0-4.8），对照组为 1.4（1.0-1.9）（p<0.001）。患者的 SF-36vs 评分逆量表均值（SD）为 58.8（23.6），健康受试者为 29.7（14.3）（p<0.001）。患者中存在有临床意义的疲劳的比例为 41%至 50%。疲劳严重程度增加与女性、年龄较小、疼痛和抑郁评分升高有关，但与包括血红蛋白在内的某些生化变量水平无关。未经治疗的乳糜泻患者疲劳是一种严重且常见的现象。
