真菌中人类致病生活方式的演变。
Evolution of the human pathogenic lifestyle in fungi.
机构信息
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Vanderbilt Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.
出版信息
Nat Microbiol. 2022 May;7(5):607-619. doi: 10.1038/s41564-022-01112-0. Epub 2022 May 4.
Abstract
Fungal pathogens cause more than a billion human infections every year, resulting in more than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology of fungi is helping us understand how disease-relevant traits have repeatedly evolved. Different types and mechanisms of genetic variation have contributed to the evolution of fungal pathogenicity and specific genetic differences distinguish pathogens from non-pathogens. Insights into the traits, genetic elements, and genetic and ecological mechanisms that contribute to the evolution of fungal pathogenicity are crucial for developing strategies to both predict emergence of fungal pathogens and develop drugs to combat them.
摘要
真菌病原体每年导致超过 10 亿人次的人类感染，每年导致超过 160 万人死亡。了解真菌的自然历史和进化生态学有助于我们理解与疾病相关的特征是如何反复进化的。不同类型和机制的遗传变异促成了真菌致病性的进化，特定的遗传差异将病原体与非病原体区分开来。了解有助于真菌致病性进化的特征、遗传要素以及遗传和生态机制，对于制定策略来预测真菌病原体的出现和开发对抗它们的药物至关重要。
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