Chierigo Francesco, Borghesi Marco, Würnschimmel Christoph, Flammia Rocco Simone, Horlemann Benedikt, Sorce Gabriele, Hoeh Benedikt, Tian Zhe, Saad Fred, Graefen Markus, Gallucci Michele, Briganti Alberto, Montorsi Francesco, Chun Felix K H, Shariat Shahrokh F, Mantica Guglielmo, Suardi Nazareno, Terrone Carlo, Karakiewicz Pierre I
Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genoa, Italy.
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.
Int Urol Nephrol. 2022 Jul;54(7):1521-1527. doi: 10.1007/s11255-022-03221-5. Epub 2022 May 4.
to compare observed overall survival vs age-adjusted lifetable (LT) derived life expectancy (LE) in metastatic urothelial bladder cancer (MBCa) patients according to race/ethnicity.
We identified Caucasian, African American, Hispanic/Latino and Asian metastatic urothelial bladder cancer patients from 2004 to 2011 within the Surveillance, Epidemiology and End Results database. Social Security Administration tables were used to compute 5 year LE. LT-derived LE was compared to observed overall survival OS. Additionally, we relied on Poisson regression plots to display cancer-specific mortality (CSM) relative to other-cause mortality (OCM) for each race/ethnicity.
Overall, 2286 MBCa patients were identified. Of those, 1800 (79%) were Caucasian vs 212 (9.3%) African American vs 189 (8.3%) Hispanic/Latino vs 85 (3.7%) Asians. The median age at diagnosis was 71 years for Asians vs 70 for Caucasians vs 67 for Hispanic/Latinos vs 67 for African Americans. African Americans showed the biggest difference between observed OS and LT-predicted LE at five years (- 83.8%), followed by Hispanic/Latinos (- 81%), Caucasians (- 77%) and Asian patients (- 69%). In Poisson regression plots, Hispanic/Latinos displayed the highest cancer-specific mortality rate (88%), while African/Americans showed the highest other cause mortality rate (12%). Conversely, Asian patients displayed the lowest CSM rate (83%) and second lowest OCM rate (7%).
African Americans showed the least favorable survival profile in MBCa, despite being youngest at diagnosis. Contrarily, Asians displayed the best survival profile in MBCa, despite being oldest at diagnosis.
根据种族/民族比较转移性尿路上皮膀胱癌（MBCa）患者观察到的总生存期与年龄调整生命表（LT）得出的预期寿命（LE）。
我们在监测、流行病学和最终结果数据库中识别出2004年至2011年期间的白种人、非裔美国人、西班牙裔/拉丁裔和亚洲转移性尿路上皮膀胱癌患者。使用社会保障管理局的表格计算5年预期寿命。将LT得出的预期寿命与观察到的总生存期（OS）进行比较。此外，我们依靠泊松回归图来展示每个种族/民族相对于其他原因死亡率（OCM）的癌症特异性死亡率（CSM）。
总体而言，共识别出2286例MBCa患者。其中，1800例（79%）为白种人，212例（9.3%）为非裔美国人，189例（8.3%）为西班牙裔/拉丁裔，85例（3.7%）为亚洲人。亚洲人诊断时的中位年龄为71岁，白种人为70岁，西班牙裔/拉丁裔为67岁，非裔美国人为67岁。非裔美国人在5年时观察到的总生存期与LT预测的预期寿命之间的差异最大（-83.8%），其次是西班牙裔/拉丁裔（-81%）、白种人（-77%）和亚洲患者（-69%）。在泊松回归图中，西班牙裔/拉丁裔显示出最高的癌症特异性死亡率（88%），而非裔美国人显示出最高的其他原因死亡率（12%）。相反，亚洲患者显示出最低的CSM率（83%）和第二低的OCM率（7%）。
非裔美国人在MBCa中的生存情况最不理想，尽管他们诊断时最年轻。相反，亚洲人在MBCa中的生存情况最佳，尽管他们诊断时年龄最大。
