Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Goethe University Frankfurt, University Hospital Frankfurt, Department of Urology, Germany.
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.
Ann Epidemiol. 2023 Mar;79:65-70. doi: 10.1016/j.annepidem.2023.01.003. Epub 2023 Jan 11.
To quantify differences in five-year overall survival (OS) between clear cell metastatic renal cell carcinoma (ccmRCC) patients and age- and sex-matched population-based controls, especially when race/ethnicity is considered.
We relied on the Surveillance, Epidemiology and End Results database (2006-2016) to identify newly diagnosed (2006- 2011) ccmRCC patients of either Caucasian, Hispanic, African American, or Asian/Pacific Islander race/ethnicity. For each case, we simulated an age- and sex-matched control (Monte Carlo simulation), relying on Social Security Administration Life Tables with five-year follow-up. We compared OS between ccmRCC patients and controls. Multivariable Cox regression models tested for race/ethnicity effect on OS.
Of 3067 ccmRCC patients, 2167 (71%) were Caucasians vs. 488 (16%) Hispanics vs. 216 (7%) African Americans and 196 (6%) Asians/Pacific Islanders. At five years, OS difference between ccmRCC patients vs. population-based controls was greatest in African Americans (11 vs. 94%, Δ = 84%), followed by Hispanics (16 vs. 94%, Δ = 77%), Caucasians (16 vs. 89%, Δ = 73%) and Asians/Pacific Islanders (19 vs. 88%, Δ = 70%). In multivariable Cox regression models, African Americans exhibited highest Hazard Ratio for death (HR 1.3, p= 0.003).
Relative to Life Tables' derived age- and sex-matched controls, ccmRCC patients exhibit drastically worse OS, especially African Americans.
量化透明细胞转移性肾细胞癌（ccmRCC）患者与年龄和性别匹配的基于人群对照者之间五年总生存率（OS）的差异，特别是考虑到种族/民族差异时。
我们依赖于监测、流行病学和最终结果数据库（2006-2016 年），以确定白人、西班牙裔、非裔美国人和亚洲/太平洋岛民种族/民族的新诊断（2006-2011 年）ccmRCC 患者。对于每个病例，我们依赖社会安全管理局生命表进行了五年的随访，模拟了年龄和性别匹配的对照者（蒙特卡罗模拟）。我们比较了 ccmRCC 患者和对照者的 OS。多变量 Cox 回归模型测试了种族/民族对 OS 的影响。
在 3067 例 ccmRCC 患者中，2167 例（71%）为白人，488 例（16%）为西班牙裔，216 例（7%）为非裔美国人，196 例（6%）为亚洲/太平洋岛民。在五年时，ccmRCC 患者与基于人群的对照者之间的 OS 差异在非裔美国人中最大（11% vs. 94%，Δ=84%），其次是西班牙裔（16% vs. 94%，Δ=77%）、白种人（16% vs. 89%，Δ=73%）和亚洲/太平洋岛民（19% vs. 88%，Δ=70%）。在多变量 Cox 回归模型中，非裔美国人的死亡风险比（HR）最高（1.3，p=0.003）。
与生命表推导的年龄和性别匹配对照者相比，ccmRCC 患者的 OS 明显更差，尤其是非裔美国人。
