胃体/胃窦交界处散在的滤泡型腺瘤伴深部囊性胃炎。

Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda.

机构信息

Pathology of Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Pathology of Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.

出版信息

BMC Gastroenterol. 2022 May 4;22(1):221. doi: 10.1186/s12876-022-02285-y.

DOI:10.1186/s12876-022-02285-y

PMID:35508985

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9066893/

Abstract

BACKGROUND

Sporadic gastric foveolar-type adenomas are extremely rare and are usually small, flat or slightly raised lesions that occur in the oxyntic mucosa.

CASE PRESENTATION

We reported here a case of a 70-year-old female with a sporadic gastric foveolar-type adenoma occurring in the mucosa at the junction of the gastric body/antrum. The adenoma was a protruding lesion of 2 × 1.8 cm sized, causing symptoms of upper gastrointestinal bleeding, and the basal and surrounding mucosa showed pseudopyloric gland metaplasia without atrophy, intestinal metaplasia, H. pylori infection, or active inflammation. It had somatic mutations in both APC and KRAS genes.

CONCLUSIONS

This is the first reported case of a large sporadic gastric foveolar-type adenoma that occurred in the mucosa of pseudopyloric gland metaplasia and with Gastritis Cystica Profunda, which modify our understanding of the morphological features and molecular underpinnings of this type of lesion.

摘要