Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital/Chinese PLA Postgraduate Military Medical School, 28 Fuxing Road, Beijing, 100853, China.
National Clinical Research Center for Digestive Diseases, Department of Gastroenterology, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China.
BMC Gastroenterol. 2022 May 4;22(1):222. doi: 10.1186/s12876-022-02302-0.
The lesions of certain diseases are widely distributed in both stomach and small intestine, while the step-by-step strategy of gastroscopy followed by enteroscopy can be burdensome and costly. We aimed to determine if magnetically controlled capsule endoscopy (MCE) could be used in one-time gastro-small intestine (GSI) joint examination.
In this study, data of patients in Chinese PLA General Hospital and Changhai Hospital who underwent MCE GSI examination from January 2020 to August 2021 were retrospectively analysed. The primary outcome of this study was the success rate of one-time GSI joint examination, and secondary outcomes included visualization and cleanliness of gastrointestinal tract, gastrointestinal transit times, diagnostic yield and safety of MCE examination.
A total of 768 patients were included. The success rate of one-time GSI joint examination was 92.58%. There were 94.92% MCEs observed > 90% gastric mucosa in the 6 anatomic landmarks. The rate of complete small bowel examination was 97.40%. The median gastric examination time, gastric transit time and small intestine transit time were 8.18 min, 63.89 min and 4.89 h, respectively. Magnetic steering of MCE significantly decreased gastric transit time (8.92 min vs. 79.68 min, P = 0.001) and increased duodenal lesion detection rate (13.47% vs. 6.26%, P = 0.001) when compared with non-magnetic steering group. Two capsules were retained and were removed by enteroscopy or spontaneously excreted.
MCE is feasible to complete GSI joint examination and the detection of both gastric and small intestinal diseases can be achieved simultaneously. Trial registration Clinical Trial Registration ClinicalTrials.gov, ID: NCT05069233.
某些疾病的病变广泛分布于胃和小肠，而胃镜检查后再进行小肠镜检查的逐步策略既繁琐又昂贵。我们旨在确定磁控胶囊内镜（MCE）是否可用于一次性胃-小肠（GSI）联合检查。
本研究回顾性分析了 2020 年 1 月至 2021 年 8 月在中国人民解放军总医院和长海医院接受 MCE GSI 检查的患者数据。本研究的主要结局是一次性 GSI 联合检查的成功率，次要结局包括胃肠道的可视化和清洁度、胃肠道转运时间、MCE 检查的诊断率和安全性。
共纳入 768 例患者。一次性 GSI 联合检查的成功率为 92.58%。在 6 个解剖学标志中，有 94.92%的 MCE 观察到>90%的胃黏膜。完整的小肠检查率为 97.40%。中位胃检查时间、胃转运时间和小肠转运时间分别为 8.18 分钟、63.89 分钟和 4.89 小时。与非磁控转向组相比，MCE 的磁转向显著降低了胃转运时间（8.92 分钟比 79.68 分钟，P=0.001），并增加了十二指肠病变的检出率（13.47%比 6.26%，P=0.001）。两个胶囊被保留，并通过小肠镜或自行排出。
MCE 可用于完成 GSI 联合检查，可同时检测胃和小肠疾病。
临床试验注册ClinicalTrials.gov，ID：NCT05069233。
Zotero 插件